FTO mediates LINE1 m6A demethylation and chromatin …
May 5, 2022 · Here, we show that FTO mediates m 6 A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA …
FTO mediates LINE1 m6A demethylation and chromatin …
May 5, 2022 · Here, we show that FTO mediates m 6 A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA …
Downregulation of the FTO m6A RNA demethylase promotes …
Jun 23, 2021 · The demethylase fat mass- and obesity-associated protein (FTO), an eraser of N6-methyladenosine (m6A), has been shown to play a role in cancer, but its contribution to tumor …
Insights into the m6A demethylases FTO and ALKBH5 : structural ...
Aug 27, 2024 · FTO and ALKBH5, as demethylases targeting m6A modification, have garnered significant attention recently. By modulating m6A levels, they actively participate in various …
The m6A demethylases FTO and ALKBH5 aggravate the malignant …
Jan 23, 2024 · We show that m 6 A levels and m6A demethylase levels are altered in nasopharyngeal carcinoma (NPC) tissues vs. normal tissues. High FTO and ALKBH5 predict a …
FTO m6A Demethylase in Obesity and Cancer: Implications and
Mar 30, 2022 · Here we review the molecular bases of m6A in tumorigenesis and adipogenesis while highlighting the controversial role of FTO in obesity. We provide recent findings …
N6-methyladenosine demethyltransferase FTO mediated m6A
Mar 5, 2024 · Gain- and loss-of-function assays revealed that FTO inhibited NSCLC tumor cell growth and metastasis in vitro and in vivo. Mechanistically, estrogen receptor alpha (ESR1) is …
Critical roles of FTO-mediated mRNA m6A demethylation in …
The roles and underlying mechanisms of FTO in lipid metabolism in adipose tissue. FTO-dependent m6A demethylation downregulates the expression of miRNA130 and miRNA155, …
Novel positioning from obesity to cancer: FTO, an m6A RNA ... - PubMed
Recently, research into the FTO gene and its expression product has attracted widespread interest due to the identification of FTO as an N6-methyladenosine (m6A) demethylase. FTO …
m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles …
Oct 31, 2023 · Here, we report that the m 6 A demethylase fat mass and obesity-associated protein (FTO) stabilizes long intergenic noncoding RNA for kinase activation (LINK-A) to …