Jul 24, 2020 · Recently, a noninvasive imaging device was developed to measure retinal flavoprotein fluorescence (FPF). Thus, oxidized FPF can act as a biomarker of mitochondrial …

Jan 1, 2022 · This review article will summarize FPF physiology and its application to retinal imaging by examining the role of mitochondrial dysfunction in retinal diseases, preclinical FPF …

Oxidative stress and mitochondrial dysfunction occur before apoptosis in many retinal diseases. Under these conditions, a larger fraction of flavoproteins become oxidized and, when excited …

Feb 16, 2023 · Despite variations in structural retinal findings, FPF was found to be highly sensitive for detecting retinal disease. Significant FPF elevation were seen in all four disease …

Aug 9, 2018 · Flavoprotein fluorescence (FPF) has been shown to be a sensitive marker of mitochondrial function and has been found to correlate with the degree of diabetic retinopathy. …

Oct 1, 2011 · Oxidative stress and mitochondrial dysfunction occur before apoptosis in many retinal diseases. Under these conditions, a larger fraction of flavoproteins become oxidized …

Prior studies have shown that retinal mitochondrial flavoproteins emit a green fluorescence (520-540 nm) when exposed to blue light (450-470 nm). The emission signal, termed flavoprotein …

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Aug 9, 2018 · Flavoprotein fluorescence (FPF) has been shown to be a sensitive marker of mitochondrial function and has been found to correlate with the degree of diabetic retinopathy. …

We investigated the specificity of flavoprotein fluorescence (FPF) to mitochondrial oxidative stress in retinal cells in vitro and its reliability as a clinical biomarker for longitudinal monitoring of …