Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a chloroformate ester. It is used to introduce the fluorenylmethyloxycarbonyl protecting group as the Fmoc carbamate.

Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.

The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base-labile amine protecting group used in organic synthesis, particularly in peptide synthesis. [1] It is popular for its stability toward acids and hydrolysis and its selective removal by weak bases, such as piperidine , without affecting most other protecting groups or sensitive ...

The classic Fmoc protection is with Fmoc-Cl under Schotten-Baumann conditions (e.g. NaHCO 3 /dioxane/H 2 O or NaHCO 3 /DMF), or with anhydrous conditions (e.g. pyridine/CH 2 Cl 2). The mechanism is attack of the nucleophilic amine to the highly …

Apr 26, 2021 · The reagent the researchers chose to install the Fmoc group was 9-fluorenylmethyloxycarbonyl chloride (Fmoc-Cl), also frequently called 9-fluorenylmethyl chloroformate. They prepared Fmoc-Cl by treating 9-fluorenylmethanol with phosgene (COCl 2).

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ChemSpider record containing structure, synonyms, properties, vendors and database links for Fluorenylmethyloxycarbonyl chloride, 28920-43-6, Fmoc-Cl, IRXSLJNXXZKURP-UHFFFAOYSA-N

9-fluorenylmethyloxycarbonyl (Fmoc) chloride | C30H21ClO4 | CID 56986206 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

9-Fluorenylmethyl Chloroformate; Product No: F0197; CAS RN: 28920-43-6; Purity: >97.0%(T)(HPLC); Synonyms: Fmoc-Cl, Chloroformic Acid 9-Fluorenylmethyl Ester, (9H-Fluoren-9-ylmethoxy)carbonyl Chloride; Appearance: White to Light yellow powder to crystaline, min. 97.0 area%, min. 97.0 %, 61.0 to 65.0 °C; contact TCI for more

Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N-Fmoc amino acids for solid-phase peptide synthesis.