Fmoc-Asp(OtBu)-OH also known as Fmoc-L-aspartic acid 4-tert-butyl ester, is a Fmoc protected amino acid, used in solid phase peptide synthesis.

Selectively protected building block for library synthesis or the preparation of β -aspartyl peptides by Fmoc SPPS.

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS of Asp-containing peptides [1]. The bulky OMpe protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu group [1,2].

Aspartimide formation leads to low yields in addition to costly purification or even inaccessible peptide sequences. Here, we report an alternative approach to address this longstanding challenge of peptide synthesis by utilizing cyanosulfurylides to mask carboxylic acids by …

Chemsrc provides Fmoc-Asp-OH (CAS#:119062-05-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Fmoc-Asp-OH are included as well.

Jan 3, 2024 · Fmoc-Asp (OtBu)-OH (4-tert-Butyl N- (fluoren-9-ylmethoxycarbonyl)-L-aspartate) is a aspartate derivative containing amine protecting group Fmoc. Fmoc-Asp (OtBu)-OH can be used for peptide synthesis [1]. [1]. Esquivel J B, et al. Chiral HPLC separation of …

Jan 27, 2025 · reaction type: Fmoc solid-phase peptide synthesis. FMOC-ASP (OALL)-OH (CAS 146982-24-3) information, including chemical properties, structure, melting point, boiling point, density, formula, molecular weight, uses, prices, suppliers, SDS and …

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Asp-Ser dipeptide motif.

Jan 27, 2025 · Fmoc-Asp(OtBu)-OH is a protected form of L-aspartic acid. It is a white to light yellow crystal powder. The molecule contains ester groups and amino groups, making it prone to polymerization and unstable over time.

Today, Fmoc SPPS is the method of choice for peptide synthesis. Very‐high‐quality Fmoc building blocks are available at low cost because of the economies of scale arising from current multiton production of therapeutic peptides by Fmoc SPPS.