The fluorenylmethoxycarbonyl protecting group (Fmoc) is a base -labile amine protecting group used in organic synthesis, particularly in peptide synthesis. [1]

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The Fmoc protecting group protects amines in synthesis, and is deprotected with bases such as secondary amines like piperidine. You might not expect it, but this group is similar to other carbamates (Boc, Cbz) despite being orthogonal. But, have you heard of Sulfmoc or Bsmoc? We will also discuss these to explain important chemistry concepts.

Fluorenylmethyloxycarbonyl chloride (Fmoc-Cl) is a chloroformate ester. It is used to introduce the fluorenylmethyloxycarbonyl protecting group as the Fmoc carbamate.

Reagent for derivatizing amino acids for HPLC amino acid analysis and for preparing N -Fmoc amino acids for solid-phase peptide synthesis.

The development of the fluorenyl methoxycarbonyl protecting group (FMOC) and its move into organic synthesis methods represents a clear breakthrough in chemistry.

A simple and efficient protection procedure is general and regioselective for the preparation of mono- N -Boc, N -Cbz, N -Fmoc or N -Alloc aromatic amines in high yield without affecting aliphatic amino groups and other functionalities.

The fluorenyl group has a strong absorbance in the ultraviolet region (lmax 266 nm in DMF) that has proved very useful for spectrophotometrically monitoring coupling and deprotection reactions. However, the Fmoc group does possess disadvantageous properties.

Fmoc resin cleavage and deprotection are crucial steps for peptide synthesis, yielding the desired peptide after resin detachment.

Aug 29, 2013 · Among the strategies for the synthesis of peptides on solid-phase, Fmoc (fluorenylmethyloxycarbonyl) and Boc (tert-butyloxycarbonyl) are most used (Miranda and Alewood 1999; Hudson 1988). In this work, our focus is the Fmoc strategy for solid phase peptide synthesis (SPPS).