Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias.

Aug 26, 2024 · FLI1 is a highly sensitive vascular marker, while CD31 is both sensitive and specific, thus confirming the vascular origin. HHV8 positivity is seen in Kaposi sarcoma among vascular tumors.

Mar 30, 2025 · FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include Bleeding Disorder, Platelet-Type, 21 and Isolated Delta-Storage Pool Disease. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

FLI-1, a member of the E26 transformation-specific (ETS) family of transcription factors, is expressed primarily in hematopoietic cells, including most cells active in immunity, and is involved in immune cell development, maintaining immune homeostasis [1].

Jun 9, 2014 · Friend leukemia virus-induced erythroleukemia-1 (Fli-1), an E26 transformation specific (ETS) transcription factor, was isolated a quarter century ago through a retrovirus mutagenesis...

The FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription.

FLI-1 is a novel and an extremely useful predictor for the poor prognosis in patients with breast cancer. The modulation of FLI-1 affected the mesenchymal characteristics, which was consistent with the changes in CSC-like phenotype.

Feb 28, 2022 · Here, we review the historical context and latest research on Fli-1, focusing on its role in hematopoiesis, immune response, and malignant transformation. The importance of identifying Fli-1 modulators (both agonists and antagonists) and …

Jan 4, 2025 · Title: FLI-1-driven regulation of endothelial cells in human diseases. FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation.

Jun 6, 2024 · FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome. Wang C, Sample KM, Gajendran B, Kapranov P, Liu W, Hu A, Zacksenhaus E, Li Y, Hao X, Ben-David YWang C, et al. Front Immunol, 2021. PMID 33717090.