Escherichia coli Nissle 1917 ghosts alleviate inflammatory bowel ...
Sep 15, 2023 · Escherichia coli Nissle 1917 (EcN) is often used in bacterial drug delivery systems to treat cancer, IBD and other diseases due to its facultative anaerobic property. This property …
Noncontact microbiota transplantation by core-shell microgel …
Feb 5, 2025 · Laser scanning confocal microscopy (LSCM) images showed the colocalization of fluorescein isothiocyanate (FITC)–labeled gelatin microspheres and EcN expressing red …
Layer-by-layer coated probiotics with chitosan and liposomes …
Jun 1, 2024 · Escherichia coli Nissle 1917 (EcN), a prototypical probiotic, is utilized in the treatment of intestinal disorders associated with inflammatory bowel disease (IBD) [5]. EcN …
Escherichia coli Nissle 1917 Protects Intestinal Barrier ... - PubMed
Jul 3, 2019 · FITC-Dextran 4,000 Da (FD-4) flux and the expression levels of tight junction (TJ) proteins were measured to evaluate the protective effect of EcN on the intestinal barrier function.
An Engineered Probiotic Produces a Type III Interferon IFNL1 and ...
In this study, a probiotic strain Escherichia coli Nissle 1917 (EcN) was engineered to promote anti-inflammatory effects via IFNL1. EcN, a robust Gram-negative probiotic commonly used for …
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by ...
Apr 1, 2025 · Escherichia coli Nissle 1917 (EcN) is genetically engineered to produce transforming growth factor-β (TGF-β) and then modified with an Eudragit L100-55 coating.
The administration of Escherichia coli Nissle 1917 ameliorates ... - PubMed
Aug 15, 2019 · Caco-2 monolayers were incubated with EcN culture supernatant (EcN sup) or SN-38 and the monolayer barrier function was assessed by transepithelial electrical resistance …
Engineered E. coli Nissle 1917 for the delivery of matrix ... - Nature
Dec 6, 2019 · We genetically engineer Escherichia coli Nissle 1917 (EcN) to create fibrous matrices that promote gut epithelial integrity in situ. These matrices consist of curli nanofibers …
Encoding bacterial colonization and therapeutic modality by …
Jan 1, 2023 · In comparison to EcN, TA@EcN demonstrated a 3.4-, 10.7-, and 10.9-fold higher inhibition against STm colonization in the jejunum, colon, and cecum, respectively (Fig. 6 J-L). …
Programmable probiotics modulate inflammation and gut …
In a mouse IBD model induced by different chemical drugs, chitosan/sodium alginate coating ECN-pE (ECN-pE (C/A) 2) effectively relieved inflammation and repaired epithelial barriers in …