Mar 22, 2021 · In brief, soxB1 (sox2) and soxC (sox4 and sox11) play an important role in formation of multiple tissues and organs in fish. Sox5 is detected in myogenic progenitor cells of O. mykiss , suggesting that sox5 can regulate myogenic cells destined to muscle formation and growth (Rescan & Ralliere 2010 ).

It was demonstrated that Sox2 is expressed in repressed neural stem cells. Therefore, we decided to investigate the expression of Sox2 in the brain of zebrafish at different ages to identify potential neurogenic areas, and to establish the developmental changes they undergo.

Nov 14, 2024 · Here they identify SOX and POU factors from unicellular relatives of animals and show that unicellular SOX can replace SOX2 to induce pluripotency, whilst unicellular POU differs from OCT4.

As an important transcription factor, SOX2 involves in embryogenesis, maintenance of stem cells and proliferation of primordial germ cell (PGC). However, little was known about its function in mature gonads. Herein, we investigated the SOX2 gene profiles in …

Sep 2, 2012 · SOX2 protein expression was assessed by IHC, and SOX2 gene copy number was assessed by FISH on a set of 110 SCLC cases and 15 normal lung controls. ( a ) Representative images showing...

Sox2 is one of the key transcription factors that play an essential role in maintaining pluripotency of stem cells. Sox2 interacts with Oct4 to form a binary complex, which then recruits other nuclear factors to activate pluripotent gene expression and repress genes involved in differentiation.

To better understand the genomic organization and evolution of Sox genes in vertebrates, we cytogenetically mapped Sox2 and Sox14 genes in cichlid fishes and performed comparative analyses of their orthologs in several vertebrate species.

Feb 8, 2025 · Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Sox2 expression in the visual system of two teleost species.

The new chromosome-level turbot genome assembly, one of the most contiguous fish assemblies to date, facilitated the identification of sox2 as a consistent candidate gene putatively driving SD in this species.

We identified upstream regulators of rx2 interrogating the rx2 pCRE in a trans -regulation screen and focused on four TFs (Sox2, Tlx, Gli3, and Her9) activating or repressing rx2 expression. We demonstrated direct interaction of the rx2 pCRE with the four factors in vitro and in vivo.