Jan 16, 2023 · Learn more about types of fibrosis, their causes, and risk factors. What Is Fibrosis? The term "fibrosis" is used to describe tissue that has overgrown, hardened, and/or scarred as a result of chronic inflammatory processes. Unlike acute …

Fibrosis, also known as fibrotic scarring, is the development of fibrous connective tissue in response to an injury. Fibrosis can be a normal connective tissue deposition or excessive tissue deposition caused by a disease.

Fibrosis is a condition that develops slowly but eventually leads to tissue degeneration, which has devastating consequences for heart, lung, liver, kidney, and skin disorders [1]. It occurs when there is an excessive buildup of fibrous connective tissue in the extracellular matrix (ECM) area of tissues that have been injured.

Human fibrotic diseases constitute a major health problem worldwide owing to the large number of affected individuals, the incomplete knowledge of the fibrotic process pathogenesis, the marked heterogeneity in their etiology and clinical manifestations, the absence of appropriate and fully validated biomarkers, and, most importantly, the ...

Fibrotic disease can affect many organs, including liver, bone marrow, lung, kidney, GI tract, skin, eye, and endomyocardium, leading eventually to organ failure.

Jun 1, 2024 · Understanding the pathogenesis and clinical implications of fibrotic diseases is crucial for developing effective therapeutic strategies and improving patient outcomes. In this review, we introduce the concept of fibrosis, discuss the mechanisms by which it arises, and explore existing and emerging therapeutic approaches in development.

Feb 15, 2024 · Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. This thickened, stiff tissue makes it harder for the lungs to work properly. Pulmonary fibrosis worsens over time.

Nov 11, 2019 · Fibrosis is defined as an excessive deposition of connective tissue components and can affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue...

Dec 30, 2019 · Background: Fibrosis is a highly dynamic process caused by prolonged injury, deregulation of the normal processes of wound healing, and extensive deposition of extracellular matrix (ECM) proteins. During fibrosis process, multiple genes interact with environmental factors.

Sep 2, 2020 · Diffuse parenchymal lung diseases encompass a large number of conditions, with a wide range of causes, clinical manifestations, and imaging and pathological features, as well as variable outcomes.