Diabetic kidney disease: m6A modification as a marker of disease ...
Mar 3, 2025 · The majority of m6A regulators exhibited significant differences across the three kinds of renal tissue samples (16/25 differential m6A regulators in whole kidney tissue, 16/26 …
N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell
May 13, 2022 · FGFR4 inhibition enhances susceptibility to anti-HER2 therapy in resistant breast cancer. Mechanistically, m6A-hypomethylation regulated FGFR4 phosphorylates GSK-3β and …
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A ...
Nov 21, 2020 · Phosphorylation of METTL3 increases interaction with USP5, decreasing ubiquitination to stabilize the m6A methyltransferase complex. Activation of the ERK …
FGFR families: biological functions and therapeutic interventions in ...
In this review, we will summarize the role of the FGFR family involved in human tumors, related regulatory signaling, and possible targeted interventions. The information offered in this review …
Dynamic landscape of m6A modifications and related post …
Oct 8, 2024 · Utilizing Nanopore direct-RNA sequencing, we characterized the m6A RNA methylation landscape in MIBC, with a focus on identifying post-transcriptional events …
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR‐Altered ...
Mar 20, 2025 · Mechanistically, COPA knockout increases the degradation of leucine-rich pentatricopeptide repeat containing (LRPPRC) protein, leading to reduced inhibitor of DNA …
The role of m6A modification in the biological functions and
Feb 21, 2021 · N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic …
New insights into the interaction between m6A modification and …
Nov 14, 2023 · In this review, we focus on the recent advancements in the interaction between m6A modification and lncRNA in the modulation of cancer drug resistance. Additionally, we …
Dysregulated m6A methylation modification is associated with …
Dec 1, 2023 · N6-methyladenosine (m6A) RNA modification and its regulatory enzymes play important roles in the modulation of inflammation by regulating inflammation-related gene …
A combined deep learning framework for mammalian m6A site …
Dec 11, 2024 · In this study, we developed an m6A site predictor called deepSRAMP, which integrates sequence-based and genome-derived features into the combination structure of a …
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