Learn about Fetroja, a cephalosporin antibacterial for the treatment of cUTI and HABP/VABP infections caused by certain susceptible Gram-negative microorganisms. Please see Important Safety Information and Full Prescribing Information on this website.

Fetroja ® (cefiderocol) is indicated in patients 18 years of age or older for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex.

Cefiderocol (Fetroja ®) is a siderophore cephalosporin that results in an iron-depleted environment of Gram-negative bacteria via the “Trojan horse” strategy. Cefiderocol has demonstrated time-dependent bactericidal activity against Gram-negative bacteria, especially those with multidrug-resistant organisms, including carbapenem-resistant ...

Cefiderocol is able to chelate ferric ions and use bacterial iron transport systems, which has been called a “Trojan Horse” strategy and translates to higher concentrations in the periplasmic space of susceptible Gram negatives

Fetroja—the world’s only siderophore cephalosporin—uses iron like a Trojan horse to actively enter bacterial cells via iron transport along with passive porin entry 1-3 To obtain iron for growth, bacteria produce siderophores, which bind to iron, and then actively transport the siderophore-bound iron into their cells to proliferate 4

Sep 3, 2020 · By combining an antibiotic with a siderophore, we sort of trick the bacteria into taking the antibiotic into the cell since the bacteria believes these siderophores are bound to iron. This approach has been coined the ‘Trojan Horse’ strategy.

Jul 5, 2022 · Cefiderocol, or Fetroja, could possibly be that fix. The brand name even hints to its novel mechanism and their website pulls on this, showing Roman soldiers going into battle with their trojan horse.

Cefiderocol, sold under the brand name Fetroja (by Shionogi) among others, is an antibiotic used to treat complicated urinary tract infections when no other options are available. [5] It is indicated for the treatment of multi-drug-resistant Gram-negative …

Dec 11, 2021 · The antibiotic Fetroja/Fetcroja penetrates bacteria like a Trojan horse. Cefiderocol, developed by Japan’s Shionogi & Co., is a new antibiotic in the cephalosporin class that works against aerobic Gram-negative bacteria.

This innovative strategy has been called “Trojan horse”, which gave this siderophore–cephalosporin the commercial name of “Fetroja”, discovered and developed by Shionogi & Co., Ltd., Osaka, Japan. This strategy overcomes the resistance mechanism of …