Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level. Iron is both necessary to the body and potentially toxic. Controlling iron levels in the body is a critically important part …

Iron is essential in many physiological processes, including DNA metabolism, oxygen transport, and cellular energy generation. Deregulated iron metabolism, which results in iron overload or iron deficiency, is observed in many different diseases.

The physiology of iron trafficking and metabolism has been well evaluated over the last 20 years, and several comprehensive reviews have been published on the subject [16, 17, 18, 19, 20, 21, 22]. Many proteins have been identified playing roles in iron metabolism.

Iron (Fe) is one of the most abundant elements of the Earth’s crust [1]. As a transition metal, its ability to donate and accept electrons in redox reactions, makes it favorable for fundamental biological processes [2].

Oct 2, 2023 · In this Review, we discuss how cells acquire, traffick and export iron and how stored iron is mobilized for iron–sulfur cluster and haem biogenesis.

Current knowledge of iron metabolism. Iron (Fe) is an essential element involved in a variety of vital functions, including oxygen transport, deoxyribonucleic acid synthesis, metabolic energy, and cellular respiration.

Dietary iron is absorbed through the mucosal cells as ferrous (Fe ++) form. Iron in diet is mostly present as ferric (Fe +++) state which is reduced to ferrous form during’ absorption. Vitamin C, glutathione and amino acid-SH groups help in reduction of ferric to ferrous form.

Jul 6, 2024 · Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if above threshold. A similar balance applies to other elements: calcium (Ca), magnesium (Mg), and trace elements including copper (Cu), zinc (Zn), lead (Pb), cadmium (Cd), mercury (Hg), and nickel (Ni).

Aug 7, 2023 · In this article, we will discuss iron metabolism in the human body, and consider the clinical consequences when this finely balanced process is disrupted. Iron is essential for the function of many enzymes and proteins, including haemoglobin.

Measuring serum iron is limited in understanding iron metabolism except in specific conditions like haemochromatosis and managing iron poisoning. Fluctuations occur due to various physiological factors such as sex, circadian rhythm, and menstrual cycle.