TTP pentad mnemonic = FAT RN. Fever, Anemia, Thrombocytopenia, Renal, Neuro Symptoms; All features DO NOT need to be present at the same time; Consider diagnosis without the full pentad; Differential Diagnosis. Other MAHAs (eg, HUS, DIC, malignant hypertension) ITP; Sepsis; SLE; HELLP syndrome

Jul 16, 2018 · These can be remembered with the mnemonic: “FAT RN”, recall: you get called by this FAT Registered Nurse telling you about the patient with Fever, Anemia, Thrombocytopenia, Renal issues and Neurological Symptoms. Treat the combination of MAHA and low platelets as TTP unless proven otherwise.

Jun 13, 2023 · Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder caused by platelet aggregation and thrombus formation in the microvasculature, resulting in severe thrombocytopenia, hemolytic anemia, and multi-organ ischemia. Annual incidence of approximately 2-4 cases/million/year (Kappler, 2017), with 90% of cases occurring in adulthood.

Apr 26, 2023 · TTP and HUS are often taught using the mnemonic ‘FAT RN,’ a pentad used to demonstrate key manifestations of the conditions. The pentad is as follows:

Dec 20, 2016 · Only 20-30% present with the classic pentad. If a patient has three or more of this pentad with schistocytes on the blood smear and a normal INR/PTT, they likely have TTP. It is important to distinguish TTP from HUS, ITP and DIC based on clinical presentation and blood tests because they are managed differently.

Two emergency thrombocytopenias: DIC and TTP. HIT too. #Thrombotic Thrombocytopenic Purpura (TTP) TTP is an emergency TTP is defined by a pentad. Mnemonic is FAT RN Fever Anemia.

Apr 7, 2023 · Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic hemolytic anemia classically characterized by the pentad of fever, hemolytic anemia, thrombocytopenia, and renal and neurologic dysfunction.

Nov 3, 2020 · TTP may be triggered by an intercurrent event (e.g. surgery, pancreatitis, sepsis, pregnancy) resulting in endothelial activation; CLINICAL FEATURES. Classic pentad (FAT R/N) fever; anaemia (microangiopathic haemolytic anaemia) thrombocytopenia; renal problems (88% have renal problems, 15% haematuria) – more likely in HUS than TTP

To help rule in/out (parenthetically expected in TTP): Hemolysis labs: retic (high), LDH (high – released in hemolysis), haptoglobin (low), bili (high), schistocytes (8.3% avg in TTP. >1% suspect TTP over mechanical hemolysis)

The pentad of symptoms seen in TTP can be remembered with the acronym "FAT RN". F is for fever, A is for anemia, and T is for thrombocytopenia. The R in RN is for renal dysfunction, while the N is for neurologic abnormalities.