Fas ligand (FASL or CD95L) is a type-II transmembrane protein expressed on various types of cells, including cytotoxic T lymphocytes, monocytes, neutrophils, breast epithelial cells, vascular endothelial cells and natural killer (NK) cells.

Accordingly, identification of the physiological ligand for FAS, called FAS ligand (FASL or CD95L) (Suda et al., 1993), through expression cloning demonstrated that it belongs to the TNF cytokine family.

For example, the Fas receptor and the cognate Fas-ligand (FasL) are constitutively expressed and transduce trophic regulatory signals in tissues such as glia, neurons, hepatocytes, and endothelium (5–7).

1 day ago · Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med. 1997;186:2045–50.

Fas Ligand is a type I integral membrane protein that is structurally related to TNFR1. It is an essential component in the induction of cell death by cytotoxic T cells (CTLs) and natural killer (NK) cells.

Fas belongs to a subgroup of family members that have a "death domain" near the carboxy-terminal region of the molecule. This domain binds to adaptor molecules that transmit a death signal to the cell. Signal transduction is complex and involves caspases, ceramides and stress pathways. Fas ligand is biologically active as a homotrimer.

Oct 1, 2009 · Fas ligand (FasL), an apoptosis-inducing member of the TNF cytokine family, and its receptor Fas are critical for the shutdown of chronic immune responses 1,2,3 and prevention of autoimmunity...

The Fas–Fas ligand (FasL) system is recognized as a major pathway for the induction of apoptosis (programmed cell death) in cells and tissues (for reviews see references 1, 2). Fas (CD95), a type I membrane protein of ∼45 kD, is a member of the …

Sep 27, 2016 · Fas and Fas Ligand (FasL) are two molecules involved in the regulation of cell death. Their interaction leads to apoptosis of thymocytes that fail to rearrange correctly their T cell receptor (TCR) genes and of those that recognize self-antigens, a process called negative selection; moreover, Fas-Fa …

Mar 15, 2006 · Fas ligand (FasL), a member of the TNF protein family, potently induces cell death by activating its matching receptor Fas. Fas-mediated killing plays a critical role in naturally and pathologically occurring cell death, including development and …