Aug 23, 2022 · Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.

People with factor V Leiden have a mutation in their coagulation factor V (F5) gene. Your F5 gene controls the production of a protein called factor V, which helps your blood clot when needed (such as after an injury). The factor V Leiden mutation changes this protein’s structure.

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. [5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. [5]

Apr 8, 2023 · Factor V Leiden (FVL) is a point mutation of factor V resulting in an elimination of the cleavage site in factor V and factor Va. This genetic defect increases the risk of thrombosis, especially in homozygous or pseudo-homozygous FVL-mutated individuals.

Factor V Leiden (rs6025 or F5 p.R506Q[1]) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability).

Oct 13, 2024 · Factor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. It can cause a disorder...

Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels.

Aug 28, 2024 · Factor V Leiden thrombophilia is a genetic condition that increases the risk of developing abnormal blood clots, known as thrombosis. It’s named after the city of Leiden in the Netherlands ...

Dec 13, 2011 · What is factor V Leiden thrombophilia? Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.

May 14, 1999 · Factor V Leiden thrombophilia is characterized by venous thromboembolism (VTE) manifesting most commonly in adults as deep vein thrombosis (DVT) in the legs or pulmonary embolism. Thrombosis in unusual locations is less common.