Sep 28, 2021 · Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE).

Feb 17, 2025 · Factor II deficiency is a very rare blood clotting disorder. It results in excessive or prolonged bleeding after an injury or surgery.

Understanding Factor II deficiency (Prothrombin deficiency), a rare bleeding disorder. Learn about the symptoms, genetics, and treatment options.

Mutations in the gene cause prothrombin deficiency. The gene provides instructions for making the prothrombin protein (also called coagulation factor II), which plays a critical role in the formation of blood clots in response to injury.

Prothrombin (also known as factor II, or FII) deficiency remains one of the rarest coagulation disorders of the rare bleeding disorders (RBDs).

Prothrombin (coagulation factor II) is encoded in the human by the F2-gene. It is proteolytically cleaved during the clotting process by the prothrombinase enzyme complex to form thrombin.

Feb 2, 2023 · Prothrombin deficiency is a disorder caused by a lack of a protein in the blood called prothrombin. It leads to problems with blood clotting (coagulation). Prothrombin is also known as factor II (factor two). When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade.

Sep 6, 2024 · Read this article to learn what a prothrombin gene mutation diagnosis may mean for your health. How is the prothrombin gene mutation inherited? The prothrombin gene mutation G20210A results from a...

This test measures how much of a protein called factor II is in your blood. Factor II is also called prothrombin. This test can help find out whether you have a bleeding or blood clotting disorder.

Mar 18, 2016 · Clotting factor II, or prothrombin, is a vitamin K–dependent proenzyme that functions in the blood coagulation cascade. Factor II deficiency is a rare, inherited or acquired bleeding disorder...