Palm-based tocotrienol-rich fraction (TRF) supplementation modulates cardiac sod1 expression, fxr target gene expression, and tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat diet

FMRP overexpression and positive regulation of Sod1 translation can directly or indirectly influence cancer progression. FXR1: Two seminal papers that define FXR1’s role in cancer drew attention in recent years (Qian, Hassanein et al. 2015, Majumder, House et al. 2016) .

Nov 15, 2023 · Dimethyl fumarate activates FXR to regulate bile acid transporters. Dimethyl fumarate suppresses the NLRP3/GSDMD pathway and thereby ameliorates hepatic inflammation. The progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury.

Intestinal epithelial cells exhibit high expression of FXR which is pivotal for intestinal function by regulating the innate immune response, reducing bacterial translocation into the intestinal wall, preserving the integrity of the epithelial barrier, and potentially reducing brotic deposi-fi tion.

The contribution of non-neuronal cells to the pathogenesis of motor neuron degeneration has been studied in mutant SOD1 mice, in which the transgene was excised in specific cell types. It was found that deleting mutant SOD1 from microglia slowed motor neuron degeneration but did not affect disease onset (Boillee et al., 2006).

the activation of farnesoid-x receptor (fxr), a bile acid receptor, and the regulation of bile acid metabolites. In the current study, we investigated the effects of TRF supplementation on ...

Mar 27, 2024 · Misfolded soluble trimeric species of superoxide dismutase 1 (SOD1) are associated with increased death in neuron-like cell models and greater disease severity in amyotrophic lateral sclerosis (ALS) patients compared to insoluble protein aggregates.

Tocotrienol-rich fraction (TRF) has been reported to protect the heart from oxidative stress-induced inflammation. It is, however, unclear whether the protective effects TRF against oxidative stress involve the activation of farnesoid-x receptor (fxr), a bile acid receptor, and the re...

Downregulation of sod1, sod2 and gpx expression was observed in TRF-treated mice; however, only sod1 was significant when compared to the HFD only group. The expression of cardiac fxr and shp was significantly upregulated, but stat3 was significantly downregulated in the TRF-treated group compared to the HFD-only group.

Mar 8, 2010 · Here we compare the physicochemical properties of SOD1 and the effects of GFP-tagging on its intracellular behaviour. Immunostaining demonstrated that SOD1 alone and GFP-SOD1 have an indistinguishable intracellular distribution in PC12 cells.