2 days ago · Since Fxr is a key nuclear receptor controlling BA homeostasis, we examined the expression of Fxr and its transcriptional targets, Shp and Bsep. While Fxr expression was unchanged, Fxr ...

Sep 1, 2000 · Through the use of a potent, nonsteroidal FXR ligand, we have identified SHP-1 as an FXR target gene in the liver of humans and rodents. Furthermore, we have demonstrated that SHP-1 can interact with LRH-1 and efficiently repress expression of CYP7A1.

Sep 30, 2008 · Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol,...

Jan 1, 2021 · The importance of FXR in the enterohepatic circulation of bile acids. FXR represses the transcriptional activity of hepatic Cyp7a1 and Cyp8b1 by upregulating the expression of SHP. FXR stimulates the synthesis of the FGF-15/19-FGFR4 pathways to …

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are key regulators of metabolism. Here, we report a previously unknown function for the hepatic FXR-SHP axis in controlling protein N-linked glycosylation.

Oct 10, 2024 · To understand the roles of hepatic FGF4 in FXR-mediated regulation of BA homeostasis, disruption of which can lead to cholestasis and hepatobiliary damage, 2, 26 we analyzed the expression levels of FXR, SHP (an indicator of FXR activation), and FGF4 in human cholestatic liver tissues.

The nuclear receptors farnesoid X receptor (FXR; NR1H4) and small heterodimer partner (SHP; NR0B2) play crucial roles in bile acid homeostasis. Global double knockout of FXR and SHP signaling (DKO) causes severe cholestasis and liver injury at early ages.

We have used a potent, nonsteroidal FXR ligand to show that FXR induces expression of small heterodimer partner 1 (SHP-1), an atypical member of the nuclear receptor family that lacks a DNA-binding domain.

Still, most FXR/RXRα target genes are maximally expressed in the presence of both ligands, including the small heterodimer partner (SHP). Here, we revisited the FXR/RXRα-mediated regulation of human SHP.

Feb 3, 2014 · FXR/CDCA-activated expression of SHP is primarily mediated through direct binding to an LRH-1 binding site, which is not modulated by LRH-1 and unresponsive to 9cRA. 9cRA-induced expression of SHP requires the IR-1 that overlaps with a …