Aug 23, 2022 · Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.

Factor V Leiden (rs6025 or F5 p.R506Q[1]) is a variant (mutated form) of human factor V (one of several substances that helps blood clot), which causes an increase in blood clotting (hypercoagulability).

Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern.

Apr 8, 2023 · Factor V Leiden (FVL) is a point mutation of factor V resulting in an elimination of the cleavage site in factor V and factor Va. This genetic defect increases the risk of thrombosis, especially in homozygous or pseudo-homozygous FVL-mutated individuals.

Heterozygous Factor V Leiden means that an individual has one copy of the mutated Factor V Leiden gene, while homozygous Factor V Leiden indicates that a person has two copies of the mutated gene.

Oct 13, 2024 · Factor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. It can cause a disorder...

Dec 13, 2011 · Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of the Caucasian (white) U.S. and European populations carry one copy of the factor V Leiden mutation, and about 1 in 5,000 people have two copies of the mutation.

Factor V Leiden causes an increased risk of developing abnormal blood clots, primarily in the veins. These clots can form deep within the veins, usually in the legs, resulting in a condition called deep vein thrombosis (DVT).

Factor V Leiden thrombophilia is an inherited disorder of blood clotting. Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels.

Apr 22, 2003 · People with factor V Leiden have a mutation in the gene for factor V. Factor V Leiden is an abnormal version of factor V that is resistant to the action of APC. Thus, APC cannot easily stop factor V Leiden from making more fibrin.