Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. [5] FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6.

In this review, we describe the multiple roles of FOXO3a in cellular stress response, with a focus on both its nuclear and mitochondrial functions. Keywords: FOXO3a, transcription factors, cellular homeostasis, stress response, nuclear/mitochondrial crosstalk. 1. Introduction.

Sep 19, 2019 · The transcription factor Forkhead box protein O3 (FOXO3a) is a core regulator of cellular homeostasis, stress response, and longevity since it can modulate a variety of stress responses upon nutrient shortage, oxidative stress, hypoxia, heat shock, and DNA damage.

Aug 26, 2014 · FoxO3a alteration is closely linked to the progression of several types of cancers, fibrosis and other types of diseases. In this review, we will examine the function of FoxO3a in disease progression and also explore FoxO3a's regulatory mechanisms.

Mar 30, 2025 · FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Hematologic Cancer and Aging. Among its related pathways are IL-9 Signaling Pathways and FOXO-mediated transcription. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding.

Jul 25, 2018 · Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer.

Jul 25, 2018 · Emerging evidences indicate that FOXO3a acts as a tumor suppressor in cancer. FOXO3a is frequently inactivated in cancer cell lines by mutation of the FOXO3a gene or cytoplasmic sequestration of FOXO3a protein. And its inactivation is associated with the initiation and progression of cancer.

FoxO3a has been found to be deregulated in several diseases and FoxO3a targeting approaches are currently underway to treat various types of cancers. This review will describe the current concept of FoxO3a’s pathological role in various diseases and elucidate the regulatory mechanisms involved.

Dec 2, 2011 · FOXO3a activation blocked the hypoxia-dependent increase in ROS and prevented HIF-1 α stabilisation. Our data suggest that FOXO factors regulate mitochondrial activity through inhibition of...

Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a tumor suppressor and longevity factor. The precise regulation of FOXO3a transactivation of target genes is achieved via post-translational modifications (PTMs) and specific protein-protein interactions.