Mar 14, 2021 · Transcription factor forkhead box P1 (FOXP1) is a crucial modulator in skeletal development and aging. Here, we determined the role and regulatory mechanisms of FOXP1 in osteosarcoma. Higher FOXP1...

Nov 1, 2005 · C-Fos expression correlated significantly with cell-cycle promoters (cyclins E and B1, cdk2 and cdk4) and cell-cycle inhibitors (p16, p21, Rb). The latter proteins are often paradoxically upregulated in human malignant carcinomas, indicating that their proliferation-inhibiting function can be overrun in tumour cells.

Taken together, we demonstrate that FOXP1, which is transactivated by ERK/JNK-c-JUN/c-FOS, drives osteosarcoma development by regulating the p53-P21/RB signaling cascade, suggesting that FOXP1 is a potential target for osteosarcoma therapy.

Sep 16, 2013 · These data demonstrate that rapid early epidermal responses to rasHa/fos/ΔPTEN co-operation involve induction of p53/p21 to alter differentiation and divert excessive proliferation into cyst...

Jun 30, 2005 · Hikasa et al. (2003) determined that c-fos overexpression led to downregulated phosphorylation and dimerization of STAT1, which in turn downregulated p21 gene expression. They concluded that this regulatory pathway may enhance the proliferation of lymphocytes in rheumatoid arthritis patients.

p21 SNFT (21-kDa small nuclear factor isolated from T cells) is a novel human protein of the basic leucine zipper family. The overexpression of p21 SNFT leads to the significant and specific repression of transcription from the interleukin-2 promoter as well as from several essential activator protein 1 (AP-1)-driven composite promoter elements.

Dec 1, 2008 · In this experiment, we address the role of ATO-induced ERK1/2 activation in the binding of c-Fos to the p21 promoter. To measure binding, ATO treatment was followed by treatment with U0126 in Flag-Fos-overexpressed A431.

The cyclin-dependent kinase (cdk) inhibitor p21(Cip1/WAF1) is a negative regulator of cdk activity, thereby impeding cell cycle progression. By sequence analysis, we identified a putative AP-1 element in the p21(Cip1/WAF1) promoter.

May 15, 2008 · Thus, Fos synergism with Pten loss elicited a benign tumour context where GSK3β-induced p53/p21 WAF expression continually switched AKT-associated proliferation into differentiation, preventing further progression.

Jan 15, 1992 · The point-mutated c-Ki-ras p21 (c-Ki-rasval12 p21) is known to strongly transform NIH/3T3 cells and to markedly stimulate the c-fos promoter/enhancer in this cell line, whereas the normal c-Ki-ras p21 is weak in these activities.