Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. [5] It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982).

Mar 30, 2025 · FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOS include Histiocytoid Hemangioma and Congenital Generalized Lipodystrophy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Feb 9, 2025 · These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. [5][6][7] The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2.

In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS / FOSB immunohistochemistry as a diagnostic tool for these lesions.

Mar 30, 2025 · FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Histiocytoid Hemangioma and Pseudomyogenic Hemangioendothelioma. Among its related pathways are IL-1 Family Signaling Pathways and ESR-mediated signaling.

Nov 1, 2005 · The Fos family of transcription factors includes c-Fos (the human homolog of the retroviral oncogene v-Fos), FosB, Fra-1 and Fra-2 as well as smaller FosB splice variants FosB2 and deltaFosB2.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

Jun 30, 2005 · FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family (see also 165160).