Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. [1] . AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis. [2] .

AP-1 is a dimeric transcription factor that contains members from the JUN, FOS, ATF and MAF protein families. AP-1 activity can be regulated by dimer composition, transcription,...

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death.

In this review, we will attempt to unravel the roles of AP-1 in the regulation of anti-tumor immune responses, with a focus on the regulation of immune checkpoints and Tregs, seeking to extract useful insights for more efficacious immunotherapy.

Mar 30, 2025 · FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOS include Histiocytoid Hemangioma and Congenital Generalized Lipodystrophy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Mar 23, 2021 · Although, members of the activator-protein-1 (AP-1) family, including Batf3, have been implicated in conventional (c)DC specification, the role of Jun proteins is poorly understood. Here, we...

Sep 1, 2021 · FOS, a subunit of the activator protein-1 (AP-1) transcription factor, has been implicated in various cellular changes. In the human ovary, the expression of FOS and its heterodimeric binding partners JUN, JUNB, and JUND increases in periovulatory follicles.

Jul 8, 2011 · Using a dominant-negative form of the AP1 protein (A-fos), we show that inhibition of the DNA binding activity of AP1 impedes the formation of accessible chromatin and reduces GR binding.

Here we show that transcriptional activation of the AP‐1 transcription factor (TF) complex members, particularly Fos, Junb, and Jun genes, is the most significant and conserved aging signature across immune cells and tissues in both short (NZO) and long‐living (B6) mice strains.

May 1, 2002 · AP-1 activity is induced by a plethora of physiological stimuli and environmental insults. In turn, AP-1 regulates a wide range of cellular processes, including cell proliferation, death,...