May 19, 2006 · Two of the most exciting and versatile genetic tools designed in the last 30 years are the Cre-lox and FLP-FRT technologies. Both allow the location and timing of gene …

In genetics, Flp-FRT recombination is a site-directed recombination technology, increasingly used to manipulate an organism's DNA under controlled conditions in vivo.

When bred with mice containing a <em>frt</em>-flanked sequence of interest, FLP-mediated recombination will result in deletion of the <em>frt</em>-flanked sequence (s) in the offspring. …

We have developed a multifunctional Cre/lox-FLP/FRT reporter mouse line (R26NZG) that uniquely combines a number of desirable features for lineage analyses. The structure of …

Ubiquitously active general Flp deleter. In vitro-derived Flp recombinase under the control of the chicken beta-actin promoter and an hCMV immediate early enhancer. The use of the chimeric …

In these mouse lines, gene knockout can be induced by Cre recombinase expression while proteins needed for later experiments (cellular tracking for instance) can be controlled with …

Mar 3, 2020 · In order to analyze the effects of increased microenvironmental TGFβ concentration in vivo, we developed a conditional transgenic mouse model (Flpo/Frt system) expressing …

Nov 26, 2009 · We generated a new FLP deleter mouse line with the mouse codon-optimized FLPo gene in C57BJ/6 background, which showed superior recombination efficacy in …

Feb 25, 2025 · Development of genetic tools, such as mice expressing Flp recombinase (Flp) in SF-1 neurons (Sf-1-Flp), will be useful for future studies that unravel the complex physiology …

011065 B6.Cg-Tg (Pgk1-flpo)10Sykr/J This FLP deleter strain is a suitable alternative to, and complement with the Cre-loxP system for <i>in vivo</i> genetic engineering and may be useful …