Fixed-dose combination (FDC) formulations are currently recommended for the treatment of active tuberculosis (TB). We have conducted a systematic review to evaluate the risk of treatment failure or disease relapse, acquired drug resistance, bacterial conversion after 2 months of treatment, adverse e …

Fixed-dose combinations (FDCs) of drugs for TB treatment have been advocated internationally to prevent the emergence of drug resistance attributable to inappropriate drug intake. 10, 11 Use of FDCs can reduce the risk of an incorrect dosage, simplify drug procurement, and aid in ensuring adherence without changing the drug dosage.

Child-friendly formulations: NTPs are encouraged to prioritize the use of child-friendly fixed dose combination (FDC) formulations for TB treatment in children up to 25 kg body weight, such as: the 3-FDC HRZ 50/75/150 mg with or without the addition of dispersible ethambutol, and the 2-FDC HR 50/75 mg (available from the Stop TB Partnership’s ...

We conducted a qualitative exploration into the palatability and acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which compares the safety and efficacy of treating non-severe drug-susceptible tuberculosis (TB) with a 6 vs. 4 ...

The use of fixed-dose combination (FDC) tablets is recommended over separate drug formulations in treatment of patients with drug-susceptible TB (Conditional recommendation, low certainty in the evidence).

FDC formulations combine several TB drugs (2, 3 or 4) in the same tablet. FDCs are only available for first-line TB drugs. FDCs improve adherence (decreased pill burden, decreased risk of omission of one or more drugs). Table 8.6 – Quality-assured FDC formulations.

We evaluated the efficacy and safety of FDC versus loose formulation (LF) TB treatment regimens for treatment of pulmonary TB (PTB) in the context of actual medical practice in prevailing conditions within programmatic settings in five sites in …

A previous study revealed that a three-drug FDC (3-FDC) regimen resulted in fewer drug-related adverse events than separate formulations (SFs) of anti-TB drugs did; however, the study method was self-administered treatment and was did not implement the DOTS 10.

WHO and other organisations recommend fixed-dose combination formulations (FDCs) as a further step to facilitate the optimal drug treatment of TB. Using FDCs in TB control will simplify the doctor's prescription and patient's drug intake, as well as the drug supply management of …

drug chemotherapy is the cornerstone of the modern approach to the control of the # and Lung Disease (IUATLD), together with their partners, recommend the use of fixed-dose combi-nation (FDC) formulations of the essential anti-tuberculosis drugs as one further step to ensure adequate treatment of patients (12, 13).