The Kinase PDK1 Is Essential for B-Cell Receptor Mediated Survival ...
Feb 5, 2013 · Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation. …
Allele-Specific MicroRNA-Mediated Regulation of a Glycolysis …
Jul 17, 2021 · We sought to identify the role of prostate cancer risk associated SNPs in regulating a vital enzyme of cancer metabolism, pyruvate dehydrogenase kinase 1 (PDK1) via …
Pyruvate dehydrogenase kinase 1 interferes with glucose …
Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondrial OXPHOS function by inhibiting …
Preclinical validation of 3-phosphoinositide-dependent protein …
May 14, 2019 · Recent evidence suggests that phosphoinositide 3-kinase (PI3K) and 3-phosphoinositide-dependent protein kinase 1 (PDK1) are key effectors of oncogenic KRAS in …
BCKDK regulates the TCA cycle through PDC in the absence of …
Apr 19, 2021 · Pyruvate dehydrogenase kinases (PDK1–4) inhibit the TCA cycle by phosphorylating pyruvate dehydrogenase complex (PDC). Here, we show that PDK family is …
Pyruvate dehydrogenase kinase 1 is essential for transplantable …
In this study, we demonstrate that Pdk1 is a HIF-1α-target gene in LSK cells in vitro, that ex vivo expanded BM colonies of Hif-1α Δ/Δ mice cultured in hypoxia are unable to express Pdk1, and …
In this study, we explored the role of pyruvate dehydrogenase kinase 1 (PDK1) in osimertinib resistance. Patients exhibiting osimertinib resistance initially displayed elevated PDK1 …
Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondrial OXPHOS function by inhibiting …
AMPK/FOXO3a Pathway Increases Activity and/or Expression of …
Western blot results at the 0-h time point showed the expression of AMPKα, ATM, DNA-PKcs, FOXO3a, SOD2, Src, EGFR, PDK1, and HIF-1α when the cells were cultured in the control …
Overexpression of pyruvate dehydrogenase kinase 1 in …
May 15, 2017 · Pyruvate dehydrogenase kinase 1 (PDK1), a key enzyme implicated in metabolic reprogramming of tumors, is induced in several tumors including glioblastoma, breast cancer …