The Fas receptor, also known as Fas, FasR, apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6), is a protein that in humans is encoded by the FAS gene.

Mar 30, 2025 · FAS (Fas Cell Surface Death Receptor) is a Protein Coding gene. Diseases associated with FAS include Autoimmune Lymphoproliferative Syndrome and Chediak-Higashi Syndrome. Among its related pathways are Dimerization of procaspase-8 and TNFR1 Pathway.

The FAS gene provides instructions for making a protein that is involved in cell signaling. Three FAS proteins group together to form a structure called a trimer, which then interacts with other molecules to perform its signaling function. This signaling initiates a process called a …

FAS (also known as APO-1 or CD95) belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that contain an intra-cellular ‘death domain’ and can trigger apoptosis. Its physiological ligand, FASL (CD95L), is a member of the corresponding TNF cytokine family.

Dec 3, 2024 · Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355).

Yan et al. (2005) described a novel RNA transcribed from the opposite strand of intron 1 of the human FAS gene, which they named SAF. The 1.5-kb transcript was expressed in human heart, placenta, liver, muscle, and pancreas, as well as in several cancer cell lines.

FAS (TNFRSF6) is the sixth member of the Tumor Necrosis Factor Receptor (TNFR) superfamily (NCBI gene ID:355). It is a membrane-bound trimeric protein playing a key role in apoptosis. The FAS gene, located on the long-arm of the chromosome 10 (10q23.3–4) in human and on the chromosome 19 in mice, is composed of 9 exons encoding a type-I protein.

Feb 8, 2025 · Gene ID: 355, updated on 8-Feb-2025. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain.

Dec 3, 2024 · The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system.

A gene encoding a soluble protein (DcR3) that competes with Fas for FasL binding has been isolated and is amplified in a number of lung and colon carcinomas 21.