The four mammalian members of the protease-activated receptor (PAR) family PAR1, PAR2, PAR3, and PAR4 are encoded by the genes F2R [1], F2RL1 [2], F2RL2 [3], and F2RL3 [4], respectively. Human PAR1 was discovered in 1991 as a key thrombin receptor on platelets [5, 6].

Mar 30, 2025 · F2RL2 (Coagulation Factor II Thrombin Receptor Like 2) is a Protein Coding gene. Diseases associated with F2RL2 include Achondroplasia and Thrombophlebitis Migrans. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Mar 30, 2025 · F2R (Coagulation Factor II Thrombin Receptor) is a Protein Coding gene. Diseases associated with F2R include Thrombosis and Blood Platelet Disease. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Jan 30, 2024 · Following F2R siRNA transfection, the downregulation of F2R in MGC-803 and SGC-7901 cell lines was confirmed through qPCR (Fig. 12D). We further investigated the impact of F2R on tumor...

Gene ID: 2151, updated on 8-Feb-2025. This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family.

Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the F2R gene. [5] . PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response.

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Jun 1, 2021 · F2rl2 mRNA was detected in populations of sensory neurons co-expressing either F2r and F2rl1 mRNAs that encode PAR1 and PAR2, respectively. Little to no overlap was observed between F2rl2 and F2rl3 (encoding PAR4) expressing sensory populations.

Sep 14, 2016 · Gene target information for F2RL2 - coagulation factor II thrombin receptor like 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Apr 8, 2021 · The genes encoding PAR1 (F2R), PAR2 (F2RL1), and PAR3 (F2RL2) are located on chromosome 5q13, while the PAR4 (F2RL3) gene is located on chromosome 19p12 [22,23].