Mar 8, 2022 · Exosomes play a role in the occurrence and development of head and neck cancer (HNC); however, the specific mechanism for their secretion remains unclear. We found that the multivesicular body gets transported to the plasma membrane for exosome secretion by exocyst via binding with Rab11a in HNC.

Sep 1, 2012 · We show here that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane.

Sep 1, 2012 · We show here that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane.

Aug 14, 2014 · RAB11 functions in conjunction with a protein complex known as the exocyst to mediate terminal steps in cargo transport via the recycling endosome to cell–cell junctions, phagosomes and...

The exocyst -- an octameric protein complex mediating vesicle tethering at the plasma membrane for exocytosis -- is a downstream effector of the Rab proteins Rab8 and Rab11, which are key regulators of membrane trafficking from the trans-Golgi ...

Oct 5, 2005 · The dual Rab11/Arf binding proteins, family of Rab11-interacting proteins FIP3 and FIP4 function in the delivery of recycling endosomes to the cleavage furrow and are, together with Rab11, essential for completion of abscission, the terminal step of cytokinesis.

Dec 17, 2021 · Rab11a, a small GTPase that is involved in MVB fusion, also interacted with the exocyst. These findings suggest that the exocyst can regulate exosome biogenesis and participate in the malignant behavior of tumor cells.

By analyzing the expression of exocyst subunits and their role in patients with HNC, we aimed to identify exo-cyst and its functions in exosome biogenesis and investigate the molecular mechanisms underlying the regulation of exosome transport in HNC cells.

Mar 24, 2014 · Acting as a molecular switch, Rab11 builds distinct molecular machinery such as motor protein complexes and the exocyst to transport proteins to the cell surface. Recent evidence reveals Rab11 localization at the trans-Golgi network (TGN), post-Golgi vesicles, and the recycling endosome, placing it at the intersection between the endocytic and ...

Mar 3, 2022 · We found that the multivesicular body gets transported to the plasma membrane for exosome secretion by exocyst via binding with Rab11a in HNC.