In adult humans, Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells. By contrast, knocking Ets1 down causes multiple defects in the immune system.

Mar 30, 2025 · Complete information for ETS1 gene (Protein Coding), ETS Proto-Oncogene 1, Transcription Factor, including: function, proteins, disorders, pathways, orthologs, and expression.

Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.

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ETS1 may be a reliable biomarker for tumor prognosis and a viable prospective therapeutic target for human cancer immunotherapy (e.g., KIRP, MESO, BLCA, KIRC, and THYM). 1. Introduction. ETS1 (ETS proto-oncogene 1, transcription factor) is a transcription factor that is mainly expressed in lymphoid cells.

The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. Some transcription ...

Structure of Ets-1 DNA binding autoinhibition. [1] In the field of molecular biology, the ETS (E26 transformation-specific[2] or Erythroblast Transformation Specific[3]) family is one of the largest families of transcription factors and is unique to animals.

ETS1 is a novel transcriptional regulator of adult T-cell leukemia/lymphoma of North American descent. ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts. Regulation of MMP9 transcription by ETS1 in immortalized salivary gland epithelial cells of patients with salivary hypofunction and primary Sjogren's syndrome.

Dec 26, 2023 · ETS1 plays multiple regulatory roles in immune-related diseases and acts as a transcriptional activator or inhibitor of many genes to regulate immune cell differentiation, development, apoptosis, and tumor occurrence. The expression level of ETS1 is correlated with disease severity.

Jul 16, 2020 · By generating ETS1 -deficient human embryonic stem cells and by expressing the dominant-negative ETS1 p27 isoform in cord blood hematopoietic progenitor cells, we show that the transcription factor ETS1 is critically required for human NK cell differentiation.