We investigated the mechanism of mutant p53 binding by mapping the human genomic binding sites for p53 R273H using ChIP-Seq and showed them to localize to ETS DNA sequence …

Aug 1, 2002 · Chromatin immunoprecipitations demonstrated that Ets1 was required for the formation of a stable p53–DNA complex under physiological conditions and activation of …

Mar 21, 1996 · In situ hybridization analyses of ETS1 and ETS2 expression during mouse embryogenesis, have shown a pattern similar to that of p53 gene expression. Significantly, we …

Oct 30, 2003 · We demonstrate that p53 and ets-1 coregulate TXSA in an antagonistic and inter-related manner, with ets-1 being a potent transcriptional activator and p53 inhibiting ets-1 …

Jan 9, 2009 · Here we show that Ets-1 also binds cooperatively to the EBS palindrome of the human p53 promoter, despite the presence of a degenerate EBS to which Ets-1 cannot …

Transcriptional activation of the MDR1 promoter by mutant p53 required an Ets binding site, and mutant p53 and Ets-1 synergistically activated MDR1 transcription. Biochemical analysis …

Recently, preferential binding of ETS2 to gain-of-function mutant p53 and ETS1 to wild type p53 (WTp53) has been suggested, raising the tumor promoting role for the former and tumor …

Jan 30, 2014 · We investigated the mechanism of mutant p53 binding by mapping the human genomic binding sites for p53 R273H using ChIP-Seq and showed them to localize to ETS …

Mar 21, 1996 · It is shown that mouse ES cells lacking Ets1 are deficient in their ability to undergo UV‐induced apoptosis, similar to p53 null ES cells, and suggests that Ets 1 may contribute to …

Apr 28, 2017 · ETS2 functions with p53-GOF mutants to epigenetically regulate super-enhancers. ETS factors function in both cell-autonomous and non-cell-autonomous manners in the tumour …