A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Developmental Cell, doi: 10.1016/j.devcel.2022.09.003, 2022.

Here, we show a mechano-chemical regulatory sys-tem underlying lung branching morphogenesis, orchestrated by extracellular signal-regulated kinase (ERK) as a downstream …

Feb 26, 2024 · Here, we show a mechano-chemical regulatory system underlying lung branching morphogenesis, orchestrated by extracellular signal-regulated kinase (ERK) as a downstream …

Jun 23, 2020 · We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues.

Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in various physiological and pathological processes. Extensive research has elucidated the signaling …

In particular, we used FRET cell imaging technique to detect kinase activity and clarified that extracellular signal-regulated kinase (ERK) activity is mechano-sensitive and generates active …

Here we explore the impact of ERK-mediated mechanical interactions on tissue morphogenesis, cell extrusion in homeostasis, and their interplay with the physical microenvironments of the …

My laboratory focuses on a number of host and pathogen proteins that play important roles in infectious diseases. The project encompasses studies of molecular mechanisms of bacterial …

In this study, we investigate whether IL11-stimulated ERK/P90RSK can phosphorylate LKB1 (STK11) to inac-tivate LKB1/AMPK and increase mTOR activity.

Thus, we found that Cif induces a potent and selective activation of the pro-survival mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. We …