The MEK1/2-ERK Pathway Inhibits Type I IFN Production in
Feb 26, 2018 · These results indicate that the MEK1/2-ERK pathway inhibits TLR9-mediated type I IFN production in pDCs and that pharmacological targeting of MEK1/2-ERK signaling could …
IL-6/ERK signaling pathway participates in type I IFN ... - Nature
Feb 1, 2023 · In the present study, we demonstrate that IFN-I additionally trigger monocytes to produce IL-6, which cooperates with IL-4 to shape the M2-skewed macrophage phenotype. …
The balance between IFN-γ and ERK/MAPK signaling activities …
Mar 25, 2025 · Here, we describe a mechanism that preserves the ISC population mediated via the synchronized, progressive activation of interferon-γ (IFN-γ) and inactivation of extracellular …
ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by ...
May 31, 2018 · In this paper, we have reported that the ERK negatively regulated IFN-γ signaling by ubiquitination of STAT1 in ESCC cells. We also found that MG132 induced apoptosis is …
DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN …
Feb 21, 2024 · In this study, we identified a critical regulatory function of the DUSP4 phosphatase in innate immune signalling. We found that DUSP4 regulates the activation of TBK1 and …
IFN-gamma + LPS induction of iNOS is modulated by ERK, …
We found that extracellular signal-regulated kinase (ERK) augmented and p38(mapk) inhibited IFN-gamma + LPS induction of iNOS. Dominant-negative MAPK kinase-4 inhibited iNOS …
ERK is integral to the IFN-γ-mediated activation of STAT1, the ...
Sep 1, 2010 · In this study, we demonstrate that the IFN-gamma-mediated phosphorylation of STAT1 on Ser (727), crucial for its maximal activity, was attenuated in human macrophages by …
Frontiers | The MEK1/2-ERK Pathway Inhibits Type I IFN …
Feb 26, 2018 · These results indicate that the MEK1/2-ERK pathway inhibits TLR9-mediated type I IFN production in pDCs and that pharmacological targeting of MEK1/2-ERK signaling could …
The IFN-γ–p38, ERK kinase axis exacerbates neutrophilic chronic ...
Feb 25, 2019 · We further demonstrated that IFN-γ induced the EMT via the p38 and extracellular signal-regulated kinase (ERK) pathways in a manner distinct from the hypoxia-inducible factor …
The MEK1/2-ERK Pathway Inhibits Type I IFN Production in …
Feb 26, 2018 · Our results suggest that the MEK1/2-ERK-dependent expression and phosphorylation of c-FOS exerts an intrinsic block of TLR9-mediated production of type I IFN. …