ERK Activation Pathways Downstream of GPCRs - PubMed
This review describes the present knowledge of the different mechanisms of ERK activation downstream of GPCRs and our present understanding of receptor-dependent and …
Diversity of G Protein-Coupled Receptor Signaling Pathways to ERK…
G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in Rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate …
Non-canonical β-adrenergic activation of ERK at endosomes
Oct 26, 2022 · G-protein-coupled receptors (GPCRs), the largest family of signalling receptors, as well as important drug targets, are known to activate extracellular-signal-regulated kinase …
G-Protein-Coupled Receptors Signaling to MAPK/Erk
2 days ago · G protein-coupled receptors (GPCRs) are activated by a wide variety of external stimuli. Upon receptor activation, the G protein exchanges GDP for GTP, causing the …
Minireview: Targeting GPCR Activated ERK Pathways for Drug …
One of the major cellular effectors activated by GPCRs is extracellular signal-regulated kinase (ERK). Both G-protein and β-arrestin mediated signaling pathways can lead to ERK activation. …
ERK Activation Pathways Downstream of GPCRs - ScienceDirect
Jan 1, 2018 · Activation of ERK specifically through the βγ subunits has been shown for Gαi-coupled GPCRs, such as the muscarinic, adrenergic, dopamine, adenosine, and LPA …
GPCR screening via ERK 1/2: a novel platform for screening G protein ...
The authors have developed a new high-throughput homogeneous assay platform for GPCR discovery as an alternative to current assays, which employs detection of phosphorylation of …
Signal transduction at GPCRs: Allosteric activation of the ERK
Oct 24, 2023 · Over the last two decades, ERK1/2 have been the most intensely studied signaling proteins scaffolded by β-arrestins. Here, we demonstrate that β-arrestins play an active role in …
Arrestin orchestrates cross-talk between GPCRs to modulate the ...
Jan 1, 2010 · Adrenergic receptors on cardiac fibroblasts were manipulated to examine the role of arrestin in the spatiotemporal regulation of ERK1/2 MAPK signaling. We show a general …
The Stability of the G Protein-coupled Receptor-β-Arrestin …
These data suggest that the C-terminal tail of a GPCR, by determining the stability of the receptor-β-arrestin complex, controls the extent of β-arrestin-bound ERK activation, and influences both …