- Copilot Answer
Dual-specificity phosphatase 6 (DUSP6): a review of its …
DUSP6 overexpression decreased ERK phosphorylation but increased anchorage-independent growth and invasive ability of their immortal mouse melanocytes. Ectopic expression of active MEK increased p-ERK levels, …
DUSP6 is a memory retention feedback regulator of ERK ... - Nature
Apr 7, 2023 · In this study, we suggest that DUSP6 is a memory-retention feedback regulator of ERK signaling for cellular resilience of hPSCs after cell dissociation. To investigate how …
DUSP6 is a memory retention feedback regulator of ERK signaling …
In this study, we suggest that DUSP6 is a memory-retention feedback regulator of ERK signaling for cellular resilience of hPSCs after cell dissociation. To investigate how hPSCs respond to …
Dusp6 is a genetic modifier of growth through enhanced ERK activity
Jan 1, 2019 · DUSP6 is a broadly expressed dual-specificity phosphatase protein, which binds and dephosphorylates extracellular-signal-regulated kinase (ERK), leading to decreased ERK …
- Author: Andy H Vo, Kayleigh A Swaggart, Anna Woo, Quan Q Gao, Alexis R Demonbreun, Katherine S Fallon, Matti...
- DOI: 10.1093/hmg/ddy349
- Publish Year: 2018
- Publication: Hum Mol Genet. 2019 Jan 15; 28(2): 279-289.
DUSP5 and DUSP6, two ERK specific phosphatases, are markers of …
Sep 14, 2017 · ERK is negatively feedback-regulated by Dual Specificity Phosphatases (DUSPs), especially two ERK-specific DUSPs, DUSP5 (nuclear) and DUSP6 (cytosolic). These negative …
- People also ask
Dual-specificity phosphatase 6 (Dusp6), a negative regulator of …
Aug 25, 2013 · Dual-specificity phosphatase 6 (Dusp6) is a negative feedback mechanism of fibroblast growth factors (FGFs)/mitogen-activated protein kinase (MAPK)/ERK1/2 signaling.
- Author: Hui Zhang, Qiufen Guo, Chong Wang, Lei Yan, Yibing Fu, Mingjun Fan, Xingbo Zhao, Mingjiang Li
- Publish Year: 2013
Targeting dual-specificity phosphatases: manipulating MAP kinase ...
DUSP6 experiences a 25-fold increase in catalytic activity when complexed to its phosphorylated substrate, ERK2 (Ref. 87).
CIC Is a Mediator of the ERK1/2-DUSP6 Negative …
Nov 20, 2020 · DUSP6 functions as an important negative feedback component of the MAPK/ERK signaling pathway. Although DUSP6 expression is tightly regulated by ERK1/2 signaling, the molecular mechanism of this regulation …
DUSP6 is a memory retention feedback regulator of ERK
Apr 7, 2023 · DUSP6 depletion using the CRISPR/Cas9 system reveals that DUSP6 suppresses the ERK activity over the long term. Elevated ERK activity by DUSP6 depletion increases both …
Related searches for Erk DUSP6
