Aug 17, 2020 · The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting ...

Jun 23, 2020 · ERK and RSK interfere with AMPK activation by inhibiting LKB1 and thus suppress PGC1α-dependent mitochondrial biogenesis. Conversely, AMPK inhibits ERK signalling by phosphorylating and ...

Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.

AMPK is a highly conserved sensor of intracellular adenosine nucleotide levels that is activated when even modest decreases in ATP production result in relative increases in AMP or ADP. In response, AMPK promotes catabolic pathways to generate …

In melanoma cells, oncogenic BRAF constitutively activates the extracellular signal-regulated kinase (ERK) pathway and phosphorylates liver kinase B1, an upstream activator of 5' adenosine monophosphate-activated protein kinase (AMPK), resulting in …

Aug 14, 2023 · LKB1 acts as a critical factor to activate AMPK, while there is ample evidence that inhibiting the MAPK can activate the LKB1-AMPK signaling pathway. The study indicated that ERK and AMPK activities were found to be negatively correlated in melanoma cells harboring the …

Nov 14, 2019 · Wang et al. (8) has demonstrated that AMPK is an upstream regulator of extracellular signal-regulated kinase (ERK) in autophagy. The ERK (also known as Erk1/2) signaling pathway is indispensable in controlling diverse cellular processes (9). Erk1/2 also participates in the regulation of autophagy.

Aug 17, 2020 · Blocking hyperactive Ras/RAF/MEK/ERK (MAPK) signaling by MAPK inhibitors in Ras/RAF-mutated cancer cells elevates autophagic flux through relieving LKB1/AMPK/ULK1 axis and inhibiting glycolysis and mitochondrial functions, which leads to drug tolerance and/or acquired resistance.

Apr 21, 2020 · AMPK is critical for cell survival under ND, as it inhibits protein elongation to conserve energy, via phosphorylating eEF2K. Although AMPK can physically interact with ERK1/2 (16,17), the results of the present study indicated that AMPK can also inhibit the interaction between eEF2K and MEK1/2 in the MEK1/2-ERK1/2-p90RSK-eEF2K-MEK1/2 feedback ...

Apr 12, 2013 · Inhibition of ERK signalling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signallings and reversed ER stress-induced insulin resistance in L6 myotubes. These findings suggest that ERK signalling plays an important role in the regulation of insulin signals in muscle cells under ER stress.