Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) …
In this review, we discuss the unique structural and functional features of ERBB3 and how this information is being used to develop effective new therapeutic agents that target ERBB3 in …
Jun 30, 2009 · To explore the optimal way to therapeutically inhibit combinatorial, ligand-induced activation of the ErbBphosphatidylinositol 3-kinase (PI3K) axis, we built a computational …
Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced …
To explore the optimal way to therapeutically inhibit combinatorial, ligand-induced activation of the ErbB–phosphatidylinositol 3-kinase (PI3K) axis, we built a computational model of the ErbB …
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen ...
Major downstream effectors of ErbB are the PI3K-AKT-mTOR-S6 kinase and RAF/MEK/ERK axes that modulate the anabolic and proliferative signals . The PI3K-AKT pathway, in …
Evaluation of co‑inhibition of ErbB family kinases and PI3K for …
A combination therapy of afatinib (ErbB inhibitor) and copanlisib (PI3K inhibitor), both Food and Drug Administration-approved kinase inhibitors, can suppress the growth of human …
ErbB Receptors and Cancer - SpringerLink
Aug 9, 2017 · The activated ErbB receptors bind to many signaling proteins and stimulate the activation of many signaling pathways , including the Ras -Raf -Mek -ERK, PI3K -Akt -Tor, …
Evaluation of co‑inhibition of ErbB family kinases and PI3K
Jan 31, 2025 · A combination therapy of afatinib (ErbB inhibitor) and copanlisib (PI3K inhibitor), both Food and Drug Administration‑approved kinase inhibitors, can suppress the growth of …
ERBB3-independent activation of the PI3K pathway in EGFR
Mar 15, 2015 · ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR …
Therapeutically targeting ErbB3: a key node in ligand-induced ...
Jul 2, 2009 · To explore the optimal way to therapeutically inhibit combinatorial, ligand-induced activation of the ErbB-phosphatidylinositol 3-kinase (PI3K) axis, we built a computational …
Impact of somatic PI3K pathway and ERBB family mutations on ...
Jul 27, 2017 · Because ERBB family mutations can activate the PI3K/AKT pathway and likely have similar canonical signalling effects to PI3K pathway mutations, we investigated their …
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