This new study by Kurokawa and colleagues highlights the role ErbB4 signaling as a critical backup system in ErbB2+ breast cancers. This study implied that Pan-ERBB inhibitors have efficacy in treating resistant tumors.

Feb 25, 2025 · Our findings indicated that ectopic expression of ERBB4 significantly enhanced TGF-β-mediated transcriptional activation using two synthetic TGF-β-responsive reporters, CAGA-luc (Figure 1 A) and SMAD-binding element (SBE)-luc (Figure S1 A), in immortalized human keratinocyte HaCaT cells.

Our current study illustrates the role of ERBB4 as a SMAD4 ki-nase, directly phosphorylating SMAD4 at Tyr162. The tyrosine-phosphorylated SMAD4 exhibits increased binding activity to chromatin and leads to enhanced expression of EMT genes upon TGF- stimulation, consequently promoting cell mobility. and facilitating lung cancer metastasis.

Feb 16, 2024 · When targeting ERBB4, at least in the CNS, a drug’s selectivity over EGFR is most crucial, as EGFR activity is key for the propagation of neural precursors and the differentiation of these into neurons, while ERBB4 is linked to schizophrenic phenotypes. 83, 84 In addition, ERBB4 is most closely related to EGFR. 85, 86 A recent study reported ...

Mar 30, 2025 · ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with ERBB4 include Amyotrophic Lateral Sclerosis 19 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7. Among its related pathways are GPCR Pathway and Signaling by ERBB2 KD Mutants.

ERBB family fusions involving the EGFR, ERBB2 and ERBB4 genes are emerging therapeutic targets in several cancer types. Recurrent EGFR-SEPT14 fusions have previously been identified in glioblastoma and are capable of activating proliferative signaling in …

NRG1 fusions result in aberrant expression of the Epidermal Growth Factor (EGF)-like domain of neuregulin-1 (NRG1) on the cell surface, which serves as a ligand for ErbB3 (HER3) and induces the formation of heterodimers, most frequently ErbB2 …

Nov 11, 2024 · ErbB4 knock-out in PV interneurons disrupted odor-evoked responses of mitral/tufted cells, and led to increased power in the ongoing local field potential in awake mice.

May 28, 2021 · Fusions within the ErbB family of receptor tyrosine kinases, including EGFR, ERBB2 (HER2) and ERBB4 (HER4), have been previously described and represent potentially actionable alterations. Here, we report the relative incidence and functional characterization of these rare genomic events.

Jul 3, 2000 · There are four members of the ErbB family: epidermal growth factor (EGF) receptor (also termed ErbB1/HER1), ErbB2/Neu/HER2, ErbB3/HER3 and ErbB4/HER4. We will refer to them, henceforth, as the ErbB receptors.