Mar 30, 2025 · EPHB4 (EPH Receptor B4) is a Protein Coding gene. Diseases associated with EPHB4 include Capillary Malformation-Arteriovenous Malformation 2 and Lymphatic Malformation 7. Among its related pathways are GPCR Pathway and EPH-Ephrin signaling.

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. [5] [6] Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system.

Jun 20, 2022 · We report that EphB4 agonism provides no additional anti-tumoral benefit in the absence of ephrinB2. These results identify ephrinB2 as a tumor promoter and its receptor, EphB4, as a tumor...

Here, we focus on EphB4 and review recent developments in elucidating its role in upper aerodigestive malignancies to include lung cancer, head and neck cancer, and mesothelioma. In particular, we summarize information regarding EphB4 structure/function and role in …

This review discusses the structure and function of the EphB4 receptor, analyzes its potential as a target for anticancer therapy, and summarizes the information about inhibitors of EphB4 kinase activity. Conclusively, EphB4 is a challenging but promising therapeutic target in cancer.

This article addresses the structure and function of the EphB4 receptor, analyses its possibility as an anticancer therapeutic target, and summarises knowledge of EphB4 kinase inhibitors. To summarise, EphB4 is a difficult but potential treatment option for cancers.

EphB4, a member of the largest family of receptor tyrosine kinases, is normally expressed on endothelial and neuronal cells. Although aberrant expression of EphB4 has been reported in several human tumors, including breast cancer, its functional significance is not understood.

Oct 22, 2019 · Here, we show that high expression of EPHB4 correlated with poor survival in prostate cancer patients and EPHB4 inhibition induced cell death in both hormone sensitive and castration-resistant...

EPHB4 and ephrin B2 show bidirectional signaling, whereby activation of EPHB4 results in forward signaling in the receptor-expressing cell, and activation of ephrin B2 results in reverse signaling in the ligand-expressing cell.

EphB4 is a critical component of the CYP2C9- and 11,12-EET-activated signaling cascade that promotes angiogenesis in vitro as well as in vivo. Overexpression of EphB4 is associated with tumour advancement of ovarian cancers; EphB4 expression was found in 44 (72.1%) out of 61 cancer tissues analysed.