Nov 1, 2024 · To explore the mechanisms by which sensory nerve EP4 affects HO, we performed RNA-sequencing on lesion tissues of the Achilles tendon collected at 10 weeks after surgical …

Mar 19, 2020 · Here, we found that after sensory denervation, knockout of the EP4 receptor in sensory nerves, or knockout of COX-2 in osteoblasts, could significantly promote adipogenesis …

Jan 14, 2019 · Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation by inhibiting sympathetic …

EP4 expression in the sensory fibers of aged mouse bone marrow with no significant decrease of the CGRP+ nerve fibers (Fig. 3f, g). We then induced ablation of EP4 in sensory nerves …

Nov 5, 2024 · Previous research has shown that sensory nerve prostaglandin E2 receptor 4 (EP4) signaling not only governs pain perception but also influences bone formation. However, the …

Oct 17, 2022 · As EP4 is responsible for PGE2-mediated bone formation (Yoshida et al., 2002), we utilized EP4 Avil −/− mice, which have a specific ablation of EP4 in sensory nerves and …

Jan 27, 2022 · EP4 expression in primary DRG neurons was increased more than 10-fold relative to treatment with Mg 2+ alone (Fig. 6a). We then generated EP4 Avil −/− mice by crossing …

Aug 2, 2021 · In this study, we investigated whether treatment with a low-dose COX-2 inhibitor maintains appropriate PGE2/EP4-mediated skeletal interoception-induced activity, thereby …

Sep 1, 2021 · Knockout of EP4 in sensory nerve increases expression of NPY causing bone catabolism and fat anabolism. Importantly, inhibition of NPY Y1 receptor (Y1R) accelerated …

Specific deletion of the major PGE2 producing enzyme cyclooxygenase 2 (COX2) in osteoblasts or PGE2 receptor EP4 in peripheral nerve markedly ameliorates OA symptoms. …