Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences.

Mar 28, 2025 · ELK1 (ETS Transcription Factor ELK1) is a Protein Coding gene. Diseases associated with ELK1 include Non-Syndromic X-Linked Intellectual Disability and Autism Spectrum Disorder. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Mar 15, 2011 · The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site.

Elk-1 plays an important role in the regulation of cellular proliferation and apoptosis, thymocyte development, glucose homeostasis and brain function. The biological function of Elk-1 relies essentially on the interaction with other proteins.

Transcription Factor Elk-1 is a protein that belongs to the AP-1 family of transcription factors. It forms a complex with the serum response factor (SRF) and binds to the serum response element (SRE) in the c-Fos promoter, playing a role in gene expression regulation in the brain.

Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase ERK at multiple sites potentiates recruitment of the Mediator transcriptional coactivator complex and transcriptional activation, but the roles of individual phosphorylation events remained unclear.

Dec 1, 2008 · Chromatin immunoprecipitation experiments revealed that the phosphorylated form of Elk-1, a key regulator of gene transcription driven by serum response element (SRE), binds to the 5'-upstream region of the Egr-1 gene in buserelin-stimulated gonadotrophs.

Oct 14, 2016 · Elk-1 (also called p62TCF), a transcription factor involved in the induction of the expression from the c-fos promoter through the promoter’s serum response element, is known to be activated as a result of phosphorylation by the MAP kinases ERK1 and ERK2.

Oct 19, 2022 · We established the transcriptional activator Elk-1 as the top regulator of RGC gene expression associated with axon outgrowth in both models. We demonstrate that Elk-1 is necessary and...

The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with a dimer of serum response factor (SRF) at the SRE ...