Nov 16, 2006 · We recently showed that expressing Egr-1 in M1myc cells abrogated the c-myc-mediated block in terminal myeloid differentiation, with the cells undergoing macrophage maturation in the absence of growth arrest. Importantly, Egr-1 also abrogated c-myc-driven leukemogenicity.

Aug 1, 2005 · Here we show that restoring expression of Egr-1 in M1 cells that express deregulated c-Myc abrogates the c-Myc block in terminal differentiation, resulting in cells that undergo functional macrophage maturation. However, there is an absence of both growth arrest and cell adhesion.

Egr-1 is dominant to c-Myc- and E2F-1-, but not to c-Myb-, driven leukemia. These findings extend the notion that the molecular nature of genetic lesions responsible for leukemia determines the effectiveness of any given tumor suppressor.

Sep 15, 1998 · To better understand the function of Egr-1 as a positive modulator of monocytic differentiation, in this work we have studied the effect of ectopic expression of Egr-1 on the murine myeloblastic leukemic cell line M1, which is induced for differentiation by the physiological inducer IL-6.

Aug 1, 2005 · Here we show that restoring expression of Egr-1 in M1 cells that express deregulated c-Myc abrogates the c-Myc block in terminal differentiation, resulting in cells that undergo functional macrophage maturation. However, there is an absence of both growth arrest and cell adhesion.

Mar 23, 2021 · Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis.

Dec 27, 2010 · Here we show that ARF is necessary for c-Myc to drive transcription of a unique noncanonical target gene, Egr1. In contrast, c-Myc induces another family member, Egr2, through a canonical mechanism that is inhibited by ARF.

Jul 1, 2011 · In our recent report, we demonstrated that ARF is necessary for the induction of a novel c-Myc target gene, Egr1, and that the Myc-ARF-Egr1 pathway is critical and specific for the ability of c-Myc to induce apoptosis independently of p53. 2.

Egr-1 (Early growth response gene-1) is an immediate early gene encoding a zinc finger motif containing transcription factor. Upon cross-linking of B cell receptor (BCR), mature B cells undergo proliferation with an increase in Egr-1.

Our results indicate that Egr-1 is an in vivo regulator of tau phosphorylation and suggest that in AD brain increased levels of Egr-1 aberrantly activate an Egr-1/Cdk5/PP1 pathway, leading to accumulation of hyperphosphorylated tau, thus destabilizing the microtubule cytoskeleton.