The EDA gene provides instructions for making a protein called ectodysplasin A. This protein is part of a signaling pathway that plays an important role in development before birth.

Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene. Ectodysplasin A is a transmembrane protein of the TNF family which plays an important role in the development of ectodermal tissues such as skin in humans.

Apr 28, 2003 · EDA encodes ectodysplasin-A (EDA), a protein that is important for normal development of ectodermal appendages including hair, teeth, and sweat glands. EDA is important in the NFKappaB pathway, which involves numerous downstream genes involved in …

Mar 28, 2025 · EDA (Ectodysplasin A) is a Protein Coding gene. Diseases associated with EDA include Ectodermal Dysplasia 1, Hypohidrotic, X-Linked and Tooth Agenesis, Selective, X-Linked, 1. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Cytokine Signaling in Immune system.

EDA-A1 and EDA-A2 are the two functional molecules encoded by the EDA gene. The receptor for EDA-A1 is EDAR, whereas the receptor for EDA-A2 is X-linked EDAR. EDA-A1 is directly associated with HED and can, through hydrolysis, release the functional domain.

Hypohidrotic, or anhidrotic, ectodermal dysplasia (HED/EDA) is characterized by a triad of signs comprising sparse hair (hypotrichosis), abnormal or missing teeth (anodontia or hypodontia), and inability to sweat (anhidrosis or hypohidrosis).

We present genotype and phenotype data of 28 molecularly-characterized patients demonstrating genetic heterogeneity, variable expressivity, and intrafamilial phenotypic variability. Thirteen mutations were reported, including four novel EDA mutations, two novel EDARADD, and one novel EDAR mutations.

To identify the gene for human X-linked anhidrotic ectodermal dysplasia (EDA) (XHED; 305100), Srivastava et al. (1996) fine mapped the translocation breakpoint in an EDA patient with the translocation t(X;1)(q13.1;p36.3).

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs.

The EDA gene encodes the protein ectodysplasin-A (EDA), a member of the tumor necrosis factor (TNF) superfamily. EDA is a type II transmembrane protein with a C-terminal TNF homology domain consisting of 10 predicted anti-parallel β-sheets linked by …