3 days ago · Strongly associated with sinonasal (NK) lymphomas Associated with monoclonal B cell lymphoproliferative disorder (high grade) and immunosuppression (methotrexate) for autoimmune disease Expresses LMP1, which prevents apoptosis via bcl2 interaction Expresses EBER1, which transactivates host genes

Epstein-Barr encoding region (EBER) in situ hybridization is the methodology of choice for the detection of the Epstein-Barr virus (EBV) in tissue sections. Because of the large numbers of copies of EBERs present in latently infected cells, non-isotopic methods can be used.

Detection of Epstein-Barr virus (EBV) may be achieved by various methods, including EBV-encoded RNA (EBER) in-situ hybridization (ISH) and immunohistochemistry (IHC) for latent membrane protein (LMP-1). We compared novel automated ISH and IHC techniques in pediatric lymphoproliferative disorders wit …

Four hematopathologists independently interpreted EBV-encoded RNA (EBER) and latent membrane protein 1 (LMP1) histochemical stains from 40 cases of Hodgkin lymphoma and then reviewed the stains as a group to resolve discrepancies and to develop interpretation guidelines.

Periodically normal skeletal muscle controls are used to test the quality of unexpired reagents.

INFORM EBER (Epstein-Barr Virus Early RNA) Probe is intended for laboratory use in the qualitative in situ hybridization (ISH) detection of cells expressing Epstein-Barr encoded RNA (EBER) by light microscopy in sections of formalin-fixed, paraffin-embedded tissue stained on a BenchMark IHC/ISH instrument.This product should be interpreted by a ...

Jan 1, 2013 · Epstein–Barr encoding region (EBER) in situ hybridization is the methodology of choice for the detection of the Epstein–Barr virus (EBV) in tissue sections. Because of the large numbers of copies of EBERs present in latently infected cells, non-isotopic methods can be used.

Aug 6, 2019 · EBER-ISH and double IHC could be easily used in clinical practice with currently available automated immunostainers and adjustment of reagent treatment time, dilution ratio, and antibody reaction time.

Mar 1, 2011 · Detection of Epstein-Barr virus (EBV) may be achieved by various methods, including EBV-encoded RNA (EBER) in-situ hybridization (ISH) and immunohistochemistry (IHC) for latent membrane protein (LMP-1). We compared novel automated ISH and IHC techniques in pediatric lymphoproliferative disorders with results obtained by manual ISH.

In situ hybridization (ISH) to Epstein-Barr virus (EBV)-encoded RNA (EBER) is considered the “gold standard” for detecting and localizing latent EBV in biopsy samples.