Dec 29, 2022 · SHP-2 and the PD-1-SHP-2 signaling restrained the GM-CSF-mediated phosphorylation of HOXA10 and IRF8, which induce myeloid differentiation and monocyte/DC lineage commitment, respectively.

The enhancer of zeste homolog 2 (EZH2) is encoded by the Enhancer of zeste 2 polycomb repressive complex 2 subunit gene. EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. ...

Jan 7, 2025 · In this study we investigate a potential crosstalk between EZH2 and mRNA splicing in CML. We describe how EZH2 modulates cellular splicing patterns through the transcriptional regulation of...

Jul 28, 2020 · Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of Lys-27 in histone 3 (H3K27me3). EZH2 could also …

Jan 14, 2021 · In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted anti-tumor immunity, including enhancing T cell...

Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, along with EZH1, to be primarily responsible for mediating Polycomb-dependent gene silencing.

EZH2 harbors functional domains: WD-40 binding domain (WDB), domains I-II, two SWI3, ADA2, N-CoR and TFIIIB (SANT) domains, cysteine-rich CXC domain and evolutionarily conserved carboxy-terminal Su(var)3-9, enhancer of zeste, trithorax (SET) domain. The SET domain of EZH2 is the catalytic domain required for HMTase activity [11, 14, 28, 29].

Enhancer of Zeste 2 (EZH2) is a bona fide oncogene that is among the most highly upregulated genes in CRPC relative to localized PCa (Varambally et al., 2002). EZH2 is a core subunit of the Polycomb Repressive Complex 2 (PRC2), which also con-tains embryonic ectoderm development (EED) and suppressor of zeste 12 (SUZ12).

Both EZH2 protein and its catalytic function (H3K27me3) have been shown to promote solid tumor metastasis, although EZH2 functional inhibition has limited impact on primary tumor growth in some cancers.

Boussiotis and colleagues show that the tyrosine phosphatase SHP-2 regulates the differentiation and antitumor function of monocytes downstream of the inhibitory PD-1 receptor.