Feb 16, 2021 · Stable knockdown of EZH2 using lentiviral shRNA vector significantly reduced the proliferation, migration and invasion abilities of TNBC cell line MDA-MB-231 and MDA-MB-468, and downregulated NSD2 expression as well as the levels of H3K27me3 and H3K36me2, two histone methylation markers catalyzed by EZH2 and NSD2, respectively.

Previous studies have proven that EZH2, which mediates the tri-methylation of H3K27 and is related to gene silencing, is an important oncogenic driver and may play a potential therapeutic role in human cancers. 33–35 Recently, relevant studies have identified a tight relationship between NSD2 and EZH2.

Feb 15, 2021 · In this study, we demonstrated that EZH2 and NSD2 were overexpressed in BC compared with benign lesions and normal tissues using tissue microarray, immunohistochemistry, and bioinformatic databases. Both EZH2 and NSD2 expression were associated with pathological grade of tumor and lymph node metastasis.

Aug 8, 2023 · Furthermore, they found that EZH2 can indirectly affect the level of H3K36me2 by regulating NSD2 and NSD2 knockdown attenuates EZH2-mediated cancer cell invasion, suggesting that NSD2 is a downstream target protein of EZH2.

Mar 15, 2023 · Meanwhile, EZH2 is very closely linked to its downstream NSD2 in cancer. The transcriptional repressor, EZH2, mediates H3K27 tri-methylation, and the transcriptional activator NSD2 mediates H3K36 di-methylation. The presence of the EZH2-NSD2 HMTase axis is coordinated by the microRNA network.

NSD2, a histone methyltransferase specific for methylation of histone 3 lysine 36 (H3K36), exhibits a glutamic acid to lysine mutation at residue 1099 (E1099K) in childhood acute lymphocytic leukemia (ALL), and cells harboring this mutation can become the predominant clone in relapsing disease.

Sep 4, 2014 · In this study, we demonstrate interplay between two oncogenic proteins, MMSET and EZH2, known to methylate histone H3 on lysine 36 (H3K36) and lysine 27 (H3K27), respectively.

Sep 4, 2014 · In this study, we demonstrate interplay between two oncogenic proteins, MMSET and EZH2, known to methylate histone H3 on lysine 36 (H3K36) and lysine 27 (H3K27), respectively.

Jul 21, 2021 · Increased EZH2/NSD2 co-expression is overrepresented in CRPC, metastases and associates with shorter disease-free survival in PC patients. Coregulation of these two histone methyltransferases is a biomarker for aggressive PC and licenses them as therapeutic targets.

Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 (NSD2) is a lysine histone methyltransferase (HMTase) and bona fide oncoprotein found aberrantly expressed in several cancers, suggesting potential role for novel therapeutic strategies.