Loss-of-function mutations in the histone methyltransferase EZH2 ...
Mar 12, 2021 · We identify seven distinct EZH2 mutations leading to loss of H3K27 trimethylation via multiple mechanisms. Analysis of matched diagnosis and relapse samples reveal a …
FDA granted accelerated approval to tazemetostat for follicular ...
EZH2 mutations were identified prospectively using formalin-fixed, paraffin-embedded tumor samples, which were centrally tested using the cobas® EZH2 Mutation Test. Patients received...
Molecular characterization of EZH2 mutant patients with ... - Nature
Jun 19, 2017 · To gain more insight into EZH2 pathology, we sought to genetically characterize a cohort of 41 EZH2 -mutated MDS/MPN patients using targeted deep next-generation …
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by ... - PubMed
May 11, 2020 · By impairing T cell help, mutant EZH2 prevents induction of proliferative MYC programs. Thus, EZH2 mutation fosters malignant transformation by epigenetically …
MUTANT EZH2 INDUCES A PRE-MALIGNANT LYMPHOMA NICHE …
By impairing T cell help, mutant EZH2 prevents induction of proliferative MYC programs. Thus, EZH2 mutation fosters malignant transformation by epigenetically reprograming B cells to form …
EZH2 abnormalities in lymphoid malignancies: underlying …
Nov 21, 2019 · Among all categories of lymphomas and lymphoid leukemias, gain-of-function somatic mutations of EZH2 were mostly detected in GC-derived diffuse large B cell lymphoma …
Targeted EZH2 Inhibitors in Diffuse Large B-Cell Lymphoma …
Dec 6, 2014 · This study has shown that IHC and mutational profiles can identify patients most likely to benefit from EZH2 inhibitor treatment by highlighting their in vivo hyper-H3K27me3 …
Molecular characterization of EZH2 mutant patients with
Colony assays indicated EZH2 mutations to be mostly early events in leukemogenesis and showed a complex mutational hierarchy. Gene expression data revealed a number of …
Mutational mechanisms of EZH2 inactivation in myeloid neoplasms
EZH2, a component of the polycomb repressive complex 2, catalyses the trimethylation of histone H3 lysine 27, a chromatin mark associated with transcriptional repression. EZH2 loss-of …
Clinical Characteristics and Outcome of Patients with EZH2- Mutant ...
Nov 5, 2021 · EZH2 (chromosome 7q) mutations reported in myeloid disorders are loss of function type, with an incidence of 4-6% in published literature. Presence of EZH2 mutation has been …