Ezh2 knockout retinas display enhanced expression of markers for mature Müller glia, along with glial membrane disorganization and upregulation of GFAP, suggesting that Ezh2 also functions as a regulator of differentiation in these cells (Iida et al., 2015; Zhang et al., 2015).

Jun 15, 2017 · The binding of Ezh2 was examined using anti-Ezh2 antibody (Active Motif, 39875) and mouse IgG (BioLegend, 401302). The histone modification value of H3K4me3 and H3K27me3 were calculated as...

Here we show that mice lacking Suz12, like Ezh2 and Eed mutant mice, are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects. Consistent with this, we demonstrate that SUZ12 is required for …

Oct 2, 2020 · Increasing evidence shows that enhancer of zeste homolog 2 (EZH2), the catalytic subunit of PRC2, functions as an oncogene or tumor suppressor gene depending on the context.

May 5, 2013 · Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently suppress GC B …

Nov 1, 2004 · We report that Ezh2 expression was developmentally regulated in the myotome compartment of mouse somites and that its down-regulation coincided with activation of muscle gene expression and differentiation of satellite-cell-derived myoblasts.

Ezh2 in actin polymerization-dependent processes SET-domain-containing polycomb group protein Ezh2 such as antigen receptor signaling in T cells and in B lineage cells results in the selective loss of histone

Jun 29, 2018 · Here we report that genetic or pharmacological targeting of the epigenetic modifier Ezh2 dramatically hinders metastatic behaviour in both a mouse model of breast cancer and patient-derived xenografts reflective of the Luminal B subtype.

Jun 26, 2022 · EZH2 (Enhancer of Zeste 2), a key component of the Polycomb Repressor Complex 2 (PRC2), is required for the differentiation of Muller glia (MG) during retinal development. However, nothing is known about the roles of EZH2 and PRC2 in mature or damaged retinas.

Epigenetic regulation of gene transcription by Ezh2 and G9a mediated HKM is required for Muller glial cell survival and proliferation. Muller glia proliferation is associated with retinal detachment, epiretinal membrane, geographic atrophy and retinal degenerations.