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Nature
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A distinct metabolic response characterizes sensitivity to EZH2 ...
Feb 12, 2021 · By coupling liquid chromatography-mass spectrometry with gene and miRNA expression profiling, we found that sensitivity to EZH2i correlated with distinct metabolic …
- Author: Patrick Nylund, Alba Atienza Párraga, Jakob Haglöf, Elke De Bruyne, Eline Menu, Berta Garrido-Zabala...
- Publish Year: 2021
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH…
  Here we demonstrate that GSK126, a potent, highly selective, S -adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransfera…
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Clinical Epigenetics
https://clinicalepigeneticsjournal.biomedcen…
Symphony of epigenetic and metabolic …
May 24, 2020 · In this review, we have summarized the correlation between EZH2 and cellular metabolic activity during tumor progression and drug treatment. …
Author: Tengrui Zhang, Yueqing Gong, Hui Meng, Chen Li, Lixiang Xue
Publish Year: 2020
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The roles of EZH2 in cancer and its inhibitors - PMC
EZH2 is involved in the cell cycle, DNA damage repair, cell differentiation, autophagy, apoptosis, and immunological modulation. The main function of EZH2 is to catalyze the methylation of H3 …
Nature
https://www.nature.com › articles
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 ...
Oct 10, 2012 · Here we demonstrate that GSK126, a potent, highly selective, S -adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, …
- Author: Michael T. McCabe, Heidi M. Ott, Gopinath Ganji, Susan Korenchuk, Christine Thompson, Glenn S. Van A...
- Publish Year: 2012
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
The epigenetic role of EZH2 in acute myeloid leukemia - PMC
EZH2 regulates transcriptional activity through: (1) EZH2 induces H3K27 methylation via the PRC2 complex, leading to transcriptional repression; (2) EZH2 independently exerting a role in …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
EZH2: a novel target for cancer treatment - PMC - PubMed Central …
This review discussed in detail about inhibitors of EZH2 methyltransferase activity, inhibitors that break PRC2’s structure, suppressing EZH2 through triggering EZH2 degradation, and the …
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How does EZH2 induce a downregulation of methionine cycling-associated genes?
EZH2 mediates gene silencing by depositing H3K27me3, and its inhibition leads to increased expression of target genes. Thus, it was not directly clear how EZH2i resulted in the downregulation of methionine cycling-associated genes. Increased expression of miRNAs can downregulate target genes and was therefore a plausible mechanism.
A distinct metabolic response characterizes sensitivity to EZH2
nature.com
What is EZH2 inhibitor?
Inhibition of SAH hydrolase leads to the accumulation of SAH in MCF7 breast cancer and T24 bladder cancer cells, which finally inhibits the HMT activity of EZH2 and downregulates the level of H3K27me3 . Many highly efficient and selective EZH2 inhibitors have been identified, which include EPZ005687 , GSK343 , and GSK126 .
Symphony of epigenetic and metabolic regulation—interaction betwee…
clinicalepigeneticsjournal.biomedcentral.com
Is EZH2 a histone methyltransferase?
EZH2 acts as a histone methyltransferase mainly by its SET domain, and it could suppress or co-activate transcription in a PRC2 dependent or independent way. Histone, located in the center of nucleosome, is not just a packing protein, but a dynamic functional interface between DNA and other cell components.
EZH2: a novel target for cancer treatment - PMC - PubMed Central (PMC)
pmc.ncbi.nlm.nih.gov
Does EZH2 block H3K27 methylation?
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012;8 (11):890–896. doi: 10.1038/nchembio.1084.
The roles of EZH2 in cancer and its inhibitors - PMC
pmc.ncbi.nlm.nih.gov
What does EZH2 stand for?
The polycomb group protein enhancer of zeste homolog 2 (EZH2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype. Oncogene 24, 6269–6280 (2005). Honma, D. et al. Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor. Cancer Sci. 108, 2069–2078 (2017).
A distinct metabolic response characterizes sensitivity to EZH2
nature.com
Does EZH2 methylate H3 histone 27 lysine?
Histone methyltransferase EZH2 of the PRC2 complex promotes trimethylation of H3 histone 27 lysine, changing the structure of chromatin and limiting gene transcription. EZH2 has the ability to directly methylate a variety of target molecules, including GATA4, STAT3, β-catenin, and the lysines at positions 510, 514, and 515 of PRC2 [5 – 10].
The roles of EZH2 in cancer and its inhibitors - PMC
pmc.ncbi.nlm.nih.gov
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
S-Adenosyl-l-methionine-competitive inhibitors of the histone ...
Dec 22, 2014 · S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
Molecular Cancer
https://molecular-cancer.biomedcentral.com › articles
Bridging epigenomics and tumor immunometabolism: molecular …
Mar 8, 2025 · Additionally, EZH2 promotes tumorigenesis, invasion, and metastasis by modulating H3K27 methylation, and its elevated expression has also been linked to acquired resistance to …
Springer
https://link.springer.com › article
Targeting EZH2 in autoimmune diseases: unraveling epigenetic
4 days ago · EZH2 expression can be co-induced by Syk and mTORC1 activity in the existence of methionine (Zhang et al. 2020a). By inducing H3 K27 me3 at the BTB and CNC homology 2 …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Antitumor effects of pharmacological EZH2 inhibition on …
Mar 7, 2015 · Immunoblot and immunohistochemical analyses showed that DZNep downregulated EZH2/KPNB1 signaling in vivo, thereby inhibiting MPNST tumor cell …
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A distinct metabolic response characterizes sensitivity to EZH2 ...

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH…

Symphony of epigenetic and metabolic …

The roles of EZH2 in cancer and its inhibitors - PMC

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2 ...

The epigenetic role of EZH2 in acute myeloid leukemia - PMC

EZH2: a novel target for cancer treatment - PMC - PubMed Central …

A distinct metabolic response characterizes sensitivity to EZH2

Symphony of epigenetic and metabolic regulation—interaction betwee…

EZH2: a novel target for cancer treatment - PMC - PubMed Central (PMC)

The roles of EZH2 in cancer and its inhibitors - PMC

A distinct metabolic response characterizes sensitivity to EZH2

The roles of EZH2 in cancer and its inhibitors - PMC

S-Adenosyl-l-methionine-competitive inhibitors of the histone ...

Bridging epigenomics and tumor immunometabolism: molecular …

Targeting EZH2 in autoimmune diseases: unraveling epigenetic

Antitumor effects of pharmacological EZH2 inhibition on …

Related searches for ezh2 methionine

Related searches for ezh2 methionine