Jul 31, 2019 · We show that EZH2 mostly works as a transcriptional inducer in ACC, through cooperation with the transcription factor E2F1 and identify three positive targets involved in cell cycle regulation...

Oct 12, 2017 · Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21 Cip1). Deletion of Cdkn1a rescues the GC reaction in Ezh2 −/− mice.

Oct 12, 2017 · The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21 Cip1).

Overexpression of E2F1 in SAE2 knockdown cells showed partially restoring EZH2 mRNA level (Fig. 3G), indicating SUMOylation is critical for the transcriptional activity of E2F1.

Oct 1, 2020 · Elevated expression of EZH2, the enzymatic subunit of polycomb repressive complex 2 (PRC2), often occurs in cancer. EZH2 expression results in the silencing of genes that suppress tumor formation and metastasis through trimethylation of histone H3 at lysine 27 (H3K27me3) at their promoters.

Nov 6, 2009 · Here we describe EZH2, an oncogenic polycomb histone methyltransferase and an E2F1 target, as an important regulator of E2F1-dependent apoptosis. We show that E2F1 induces EZH2...

Here we describe EZH2, an oncogenic polycomb histone methyltransferase and an E2F1 target, as an important regulator of E2F1-dependent apoptosis. We show that E2F1 induces EZH2 expression, which in turn antagonizes the induction of E2F1 pro-apoptotic target Bim expression.

Nov 1, 2009 · Here we describe EZH2, an oncogenic polycomb histone methyltransferase and an E2F1 target, as an important regulator of E2F1-dependent apoptosis. We show that E2F1 induces EZH2...

Aug 8, 2019 · We show that EZH2 mostly works as a transcriptional inducer in ACC, through cooperation with the transcription factor E2F1 and identify three positive targets involved in cell cycle regulation and mitosis i.e., RRM2, PTTG1 and ASE1/PRC1.

Here, we show that the expression of the two PRC2 members EZH2 and EED is controlled by the E2F transcription factors. We demonstrate that EZH2 and EED are required for cell proliferation acting as essential downstream mediators of E2F function.